Spirohydantoin tricyclic CGRP receptor antagonists

Details Spirohydantoin tricyclic CGRP receptor antagonists Spirohydantoin tricyclic CGRP receptor antagonists

2011-06-28

2011-06-28

Jarrell, Noble (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S555000

Reexamination Certificate

active

07968540

ABSTRACT:
Compounds of formula I:(wherein variables A1, A2, A3, A4, A5, A6, A7, B1, B2, B3, B4, D1, D2, E1, E2, E3, E4, E5, G1, G2, R6, T, U, V, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

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Supplementary European Search Report and Search Opinion for counterpart European patent application No. EP 06 82 7801, Aug. 23, 2010.

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