Hybrid proteins with ErbB4 extracellular domain and...

Details Hybrid proteins with ErbB4 extracellular domain and... Hybrid proteins with ErbB4 extracellular domain and...

2011-08-09

2011-08-09

Kemmerer, Elizabeth C (Department: 1646)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S009600, C514S018100, C514S019300, C514S019400, C514S021200, C435S069700, C435S375000

Reexamination Certificate

active

07994123

ABSTRACT:
Polypeptides of the neuregulin (NRG) heparin binding domain (N-HBD) and nucleic acids coding therefor are disclosed. In particular, fusion polypeptides are produced that comprise, as a targeting structure, a N-HBD polypeptide, fragment, homologue or functional derivative and a protein to be targeted. This is fused to a polypeptide or peptide being targeted (P<SUB>trg</SUB>) to cell surfaces rich in heparan sulfate proteoglycans to either activate or inhibit interactions at tyrosine kinase receptors. A preferred fusion polypeptide comprises an N-HBD, a spacer and the extracellular domain of erbB4, one of several receptors signaled by NRG, which is potent NRG antagonist. Such products are used to treat diseases or conditions where either agonism or antagonism at tyrosine kinase receptors has beneficial effects, including cancer and a multitude of diseases of the nervous system.

REFERENCES:
patent: WO 03/012045 (2003-02-01), None
Plowman et al., Proc. Natl. Acad. Sci., 1993, vol. 90(5):1746-50.
Heath et al., Biochemistry, 1991, vol. 30:5608-5614.

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