Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-07-30
1980-10-28
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424258, 546176, 546278, A61K 3144, C07D40106, A61K 3147
Patent
active
042307147
ABSTRACT:
A series of 2-(imidazol-1-ylmethyl)pyridines and 2-(imidazol-1-ylmethyl)quinolines has been prepared, including their pharmaceutically acceptable acid addition salts. These particular compounds are useful in therapy for the treatment of ischaemic heart disease, migraine, transient ischaemic attack and stroke. Preferred member compounds include 2-(imidazol-1-ylmethyl)-3-methoxypyridine, 2-(imidazol-1-ylmethyl)-3-methoxy-6-methylpyridine and 2-(imidazol-1-ylmethyl)-3-benzyloxypyridine, respectively. Alternate methods of preparation are provided and the principal synthetic routes leading to the preferred compounds are described in some detail.
REFERENCES:
patent: 3417091 (1968-12-01), Pickholz et al.
patent: 4058614 (1977-11-01), Baldwin
Sundberg "J. Het. Chem.", vol. 14, pp. 1279-1281, 1977.
Cross Peter E.
Dickinson Roger P.
Bond Robert T.
Jiles Henry R.
Pfizer Inc.
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