Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-03-29
2011-03-29
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S378000, C546S272100, C548S248000
Reexamination Certificate
active
07915297
ABSTRACT:
Disclosed herein are isoxazole derivatives and uses thereof. Serving as agonists of Wnt, the isoxazole derivatives activate Wnt/β-catenin signaling and thus can be used in the treatment and prevention of diseases related to the signal transduction. Also, pharmaceutically acceptable salts of the isoxazole derivatives are disclosed.
REFERENCES:
patent: 3455837 (1969-07-01), Maeder
patent: 3852293 (1974-12-01), Ariyan et al.
patent: 5201932 (1993-04-01), Maywald et al.
patent: 5374605 (1994-12-01), Hallenbach et al.
patent: 2003/0139404 (2003-07-01), Haag et al.
patent: 2008/0090882 (2008-04-01), Dorsch et al.
patent: 2062373 (1970-12-01), None
patent: 0419944 (1990-12-01), None
patent: 0726263 (1996-10-01), None
patent: 1390402 (1975-04-01), None
patent: 1492663 (1977-11-01), None
patent: 08-027130 (1996-01-01), None
patent: 2006-176443 (2006-07-01), None
patent: WO 96/00218 (1996-01-01), None
patent: WO03/000649 (2003-01-01), None
patent: 03013517 (2003-02-01), None
patent: WO 2008/046072 (2008-04-01), None
Andersson et al. Investigation of central versus peripheral effects of estradiol in ovariectomized mice. Journal of Endocrinology (2005) 187, pp. 303-309.
Hobar et al. “Prevention of Osteoporosis.” eMedicineHealth: Pratical Guide to Health. Accessed May 20, 2009.
Machine translation of JP 2006-176443A. Obtained Dec. 8, 2009 from AIPN website.
Benincori et al. J. Chem. Soc. Perkin Trans. 1 (1993) pp. 675-680.
Bennett et al., Regulation of osteoblastogenesis and bone mass by Wnt10b, Proc. Natl. Acad. Sci. U S A, Mar. 1, 2005;102(9):3324-9, Epub Feb. 22, 2005.
He et al., BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt- bold beta -catenin signaling, Nature Genetics, Sep. 19, 2004, vol. 36, pp. 1117-1121.
Pae et al., Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles, Bioorganic & Medicinal Chemistry Letters, vol. 9, Issue 18, Sep. 20, 1999, pp. 2679-2684.
Tamai et al., LDL Receptor-Related Proteins in Wnt Signal Transduction, Nature, Sep. 28, 2000; vol. 407 pp. 530-535.
Winston et al., A family of mammalian F-box proteins, Cur.r Biol. Oct. 11, 1999, 9:1180-1182.
Andreichov, Yu S., et al., Journal of Organic Chemistry of the USSR (English Translation). YOCYA9 23(10) 1895-1996 (1987).
Afridi, Sultan A., at al. Heterocyclic Rearrangements. Part XIC. Attempts to Activate Ring-Opening-Ring-closure Rearrangements with Carbon as the Central Atom. School of Chemical Sciences, pp. 315-320. (1976).
Yarovenko, V.N. et al., Synthesis of Oxamic Acids Thiohydrazides and Carbamoyl-1, 3, 4-thiadiazoles, Russian Journal of Organic Chemistry, vol. 39, No. 8, 2003, pp. 1133-1139.
Qian, Chang-Yi, et al., Synthesis of 2,3,5-Trisubstituted Furans by the Acid-Catalyzed Decomposition of 1,2-Dioxan-3-ols., J. Heterocyclic Chem., 31, 1219 (1994).
Yokooji, Aya, et al. Palladium-catalyzed direct arylation of thiazoles with aryl bromides., Tetrahedron 59 (2003) pp. 5685-5689.
International Preliminary Report and Written Opinion dated Jun. 5, 2007.
Westendorf, Jennifer J., et al., Wnt signaling in osteoblasts and bone diseases., Gene 341 (2004) 19-39.
Fargher, Robert George, et al., LXXXVII.-The Abnormal Behaviour of Glyoxaline-carbaxylic esters and anilides towards Diazonium salts., Wellcome Chemical Research Laboratories, pp. 1015-1020, ( 1920).
Milyutin, A.V., et al., Synthesis, Properties, and Biological Activity of 3-Pyridylamides of 4-Aryl-2-hydroxy-4-oxo-2-butenic (Aroylpyruvic) acids., Pharmaceutical Chemistry Journal, vol. 31, pp. 30-33, (1997).
Bae Sung Jin
Cho Jeong Woo
Cho Kyung Chul
Choi Sang Rak
Hwang Sun Gwan
Anderson Rebecca L
Otton Alicia L
SK Holdings Co., Ltd.
LandOfFree
Isoxazole derivatives and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isoxazole derivatives and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isoxazole derivatives and use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2678485