Gene delivery vectors provided with a tissue tropism for...

Details Gene delivery vectors provided with a tissue tropism for... Gene delivery vectors provided with a tissue tropism for...

2011-06-28

2011-06-28

Chen, Shin-Lin (Department: 1632)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093200, C435S320100, C435S455000, C536S023720

Reexamination Certificate

active

07968087

ABSTRACT:
A gene delivery vehicle having been provided with at least a tissue tropism for cells selected from the group of smooth muscle cells, endothelial cells, and/or liver cells. The tissue tropism is generally provided by a virus capsid, such as one comprising protein fragments from at least two different viruses, such as two different adenoviruses, including adenovirus of subgroup C or subgroup B (for example, adenovirus 16). The protein fragments can comprise a tissue tropism-determining fragment of a fiber protein derived from a subgroup B adenovirus. Also, cells for producing such gene delivery vehicles and pharmaceutical compositions containing these gene delivery vehicles are provided. Further, a method is disclosed for delivering nucleic acid to cells such as smooth muscle cells and/or endothelial cells which involves administering to the cells an adenovirus capsid having proteins from at least two different adenoviruses and wherein at least a tissue tropism-determining fragment of a fiber protein is derived from a subgroup B adenovirus. Particular constructs are also disclosed.

REFERENCES:
patent: 4487829 (1984-12-01), Sharp et al.
patent: 4517686 (1985-05-01), Ruoslahti et al.
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4593002 (1986-06-01), Dulbecco
patent: 4792525 (1988-12-01), Ruoslahti et al.
patent: 4797368 (1989-01-01), Carter et al.
patent: 4956281 (1990-09-01), Wallner et al.
patent: 5024939 (1991-06-01), Gorman
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5166320 (1992-11-01), Wu et al.
patent: 5198346 (1993-03-01), Ladner et al.
patent: 5204445 (1993-04-01), Plow et al.
patent: 5223394 (1993-06-01), Wallner
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5240846 (1993-08-01), Collins et al.
patent: 5246921 (1993-09-01), Reddy et al.
patent: 5332567 (1994-07-01), Goldenberg
patent: 5349053 (1994-09-01), Landolfi
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5436146 (1995-07-01), Shenk et al.
patent: 5443953 (1995-08-01), Hansen et al.
patent: 5474935 (1995-12-01), Chatterjee et al.
patent: 5521291 (1996-05-01), Curiel et al.
patent: 5534423 (1996-07-01), Palsson et al.
patent: 5543328 (1996-08-01), McClelland et al.
patent: 5547932 (1996-08-01), Curiel et al.
patent: 5552311 (1996-09-01), Sorscher et al.
patent: 5559099 (1996-09-01), Wickham et al.
patent: 5571698 (1996-11-01), Ladner et al.
patent: 5585254 (1996-12-01), Maxwell et al.
patent: 5622699 (1997-04-01), Ruoslahti et al.
patent: 5693509 (1997-12-01), Cotten et al.
patent: 5698443 (1997-12-01), Henderson et al.
patent: 5712136 (1998-01-01), Wickham et al.
patent: 5731190 (1998-03-01), Wickham et al.
patent: 5756086 (1998-05-01), McClelland et al.
patent: 5770442 (1998-06-01), Wickham et al.
patent: 5837511 (1998-11-01), Falck-Pedersen et al.
patent: 5846782 (1998-12-01), Wickham et al.
patent: 5849561 (1998-12-01), Falck-Pedersen
patent: 5856152 (1999-01-01), Wilson et al.
patent: 5861290 (1999-01-01), Goldsmith et al.
patent: 5871726 (1999-02-01), Henderson et al.
patent: 5871727 (1999-02-01), Curiel
patent: 5871982 (1999-02-01), Wilson et al.
patent: 5877011 (1999-03-01), Armentano et al.
patent: 5922315 (1999-07-01), Roy
patent: 5981275 (1999-11-01), Armentano et al.
patent: 5994128 (1999-11-01), Fallaux et al.
patent: 6007806 (1999-12-01), Lathe et al.
patent: 6033908 (2000-03-01), Bout et al.
patent: 6057155 (2000-05-01), Wickham et al.
patent: 6057299 (2000-05-01), Henderson
patent: 6100086 (2000-08-01), Kaplan et al.
patent: 6127525 (2000-10-01), Crystal et al.
patent: 6287857 (2001-09-01), O'Riordan et al.
patent: 6306652 (2001-10-01), Fallaux et al.
patent: 6329190 (2001-12-01), Wickham et al.
patent: 6358507 (2002-03-01), Kaplan et al.
patent: 6417168 (2002-07-01), Greene et al.
patent: 6455314 (2002-09-01), Wickham et al.
patent: 6486133 (2002-11-01), Herlyn et al.
patent: 6492169 (2002-12-01), Vogels et al.
patent: 6632427 (2003-10-01), Finiels et al.
patent: 6669942 (2003-12-01), Perricaudet et al.
patent: 6844192 (2005-01-01), Orlando et al.
patent: 6878549 (2005-04-01), Vogels et al.
patent: 6913922 (2005-07-01), Bout et al.
patent: 6974695 (2005-12-01), Vogels et al.
patent: 7270811 (2007-09-01), Bout et al.
patent: 7285265 (2007-10-01), Vogels et al.
patent: 7300657 (2007-11-01), Pau et al.
patent: 7468181 (2008-12-01), Vogels et al.
patent: 7749493 (2010-07-01), Havenga et al.
patent: 7820440 (2010-10-01), Vogels et al.
patent: 2002/0006395 (2002-01-01), Perricaudet et al.
patent: 2002/0028194 (2002-03-01), Kaplan et al.
patent: 2002/0052485 (2002-05-01), Colosi
patent: 2002/0122789 (2002-09-01), Perricaudet et al.
patent: 2003/0026783 (2003-02-01), Abina
patent: 2003/0044383 (2003-03-01), Henderson et al.
patent: 2003/0152553 (2003-08-01), Little et al.
patent: 2005/0158278 (2005-07-01), Vogels et al.
patent: 2005/0196384 (2005-09-01), Vogels et al.
patent: 2005/0232900 (2005-10-01), Vogels et al.
patent: 2005/0244381 (2005-11-01), Mallet et al.
patent: 2005/0265974 (2005-12-01), Pau et al.
patent: 2007/0010016 (2007-01-01), McCelland et al.
patent: 2007/0041946 (2007-02-01), Bout et al.
patent: 2007/0071726 (2007-03-01), Pau et al.
patent: 2007/0207461 (2007-09-01), Weggeman et al.
patent: 2008/0131461 (2008-06-01), Pau et al.
patent: 2008/0171018 (2008-07-01), Bout et al.
patent: 2008/0199917 (2008-08-01), Vogels et al.
patent: 2008/0206837 (2008-08-01), Vogels et al.
patent: 2008/0220014 (2008-09-01), Pau et al.
patent: 2009/0017523 (2009-01-01), Weggeman et al.
patent: 2009/0253207 (2009-10-01), Vogels et al.
patent: 2009/0285879 (2009-11-01), Pau et al.
patent: 2010/0015176 (2010-01-01), Vogels et al.
patent: 2010/0034774 (2010-02-01), Vogels et al.
patent: 2010/0172928 (2010-07-01), Pau et al.
patent: 0259212 (1988-03-01), None
patent: 259212 (1988-03-01), None
patent: 99201545.3 (1999-05-01), None
patent: 0 978 566 (2000-02-01), None
patent: 1 054 064 (2004-10-01), None
patent: 1 550 722 (2007-06-01), None
patent: 1 816 204 (2007-08-01), None
patent: 2078631 (1990-03-01), None
patent: WO 91/00360 (1991-01-01), None
patent: WO 91/05805 (1991-05-01), None
patent: WO 91/05871 (1991-05-01), None
patent: WO 92/02553 (1992-02-01), None
patent: WO 92/13081 (1992-08-01), None
patent: WO 93/03769 (1993-03-01), None
patent: WO 93/06223 (1993-04-01), None
patent: WO 93/07282 (1993-04-01), None
patent: WO 93/07283 (1993-04-01), None
patent: WO 94/08026 (1994-04-01), None
patent: WO 94/10323 (1994-05-01), None
patent: WO 94/11506 (1994-05-01), None
patent: WO 94/15644 (1994-07-01), None
patent: WO 94/17832 (1994-08-01), None
patent: WO 94/24299 (1994-10-01), None
patent: WO 94/26915 (1994-11-01), None
patent: WO 95/05201 (1995-02-01), None
patent: WO 95/06745 (1995-03-01), None
patent: WO 95/14785 (1995-06-01), None
patent: WO 95/16037 (1995-06-01), None
patent: WO 95/21259 (1995-08-01), None
patent: WO 95/26412 (1995-10-01), None
patent: WO 95/27071 (1995-10-01), None
patent: WO 95/31187 (1995-11-01), None
patent: WO 95/31566 (1995-11-01), None
patent: WO 96/00326 (1996-01-01), None
patent: WO 96/00790 (1996-01-01), None
patent: WO 96/07739 (1996-03-01), None
patent: WO 96/10087 (1996-04-01), None
patent: WO 96/12030 (1996-04-01), None
patent: WO 96/13597 (1996-05-01), None
patent: WO 96/13598 (1996-05-01), None
patent: WO 96/14837 (1996-05-01), None
patent: WO 96/17073 (1996-06-01), None
patent: WO 96/18740 (1996-06-01), None
patent: WO 96/26281 (1996-08-01), None
patent: WO 96/35798 (1996-11-01), None
patent: WO 97/00326 (1997-01-01), None
patent: WO 97/01358 (1997-01-01), None
patent: WO 97/12986 (1997-04-01), None
patent: WO 97/20575 (1997-06-01), None
patent: WO 97/24453 (1997-07-01), None
patent: WO 97/38723 (1997-10-01), None
patent: WO 98/01563 (1998-01-01), None
patent: WO 98/07865 (1998-02-01), None
patent: WO 98/11221 (1998-03-01), None
patent: WO 98/13499 (1998-04-01), None
patent: WO 98/22609 (1998-05-01), None
patent: WO 98/32842 (1998-07-01), None
patent: WO 98/40509 (1998-09-01), None
patent: WO 98/46779 (1998-10-01), None
patent: WO 98/46781 (1998-10-01), None
patent: WO 98/49300 (1998-11-01), N

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