Antimicrobial quinolones, their compositions and uses

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S156000

Reexamination Certificate

active

07868021

ABSTRACT:
Compounds having the general structure:which are effective antimicrobial agents.

REFERENCES:
patent: 4017622 (1977-04-01), Minami et al.
patent: 4341784 (1982-07-01), Matsumoto et al.
patent: 4448962 (1984-05-01), Irikura et al.
patent: 4544658 (1985-10-01), Petersen et al.
patent: 4544747 (1985-10-01), Ishikawa et al.
patent: 4665079 (1987-05-01), Culbertson et al.
patent: 4771054 (1988-09-01), Domagala et al.
patent: 4780468 (1988-10-01), Bridges et al.
patent: 4822801 (1989-04-01), Domagala et al.
patent: 4844902 (1989-07-01), Grohe
patent: 4855292 (1989-08-01), Ueda et al.
patent: 4894458 (1990-01-01), Masuzawa et al.
patent: 4894578 (1990-01-01), Masuzawa et al.
patent: 4920120 (1990-04-01), Domagala et al.
patent: 4988709 (1991-01-01), Ogata et al.
patent: 4990517 (1991-02-01), Petersen et al.
patent: 4994599 (1991-02-01), Chu
patent: 4997943 (1991-03-01), Iwata et al.
patent: 5043450 (1991-08-01), Masuzawa et al.
patent: 5051509 (1991-09-01), Nagano et al.
patent: 5072001 (1991-12-01), Hagen et al.
patent: 5098912 (1992-03-01), Hayakawa et al.
patent: 5116834 (1992-05-01), Domagala et al.
patent: 5229396 (1993-07-01), Brighty
patent: 5281612 (1994-01-01), Domagala et al.
patent: 5286723 (1994-02-01), Hawakawa et al.
patent: 5328908 (1994-07-01), Demuth, Jr. et al.
patent: 5348961 (1994-09-01), Iwata et al.
patent: 5364861 (1994-11-01), Hagen et al.
patent: 5387748 (1995-02-01), Demuth, Jr. et al.
patent: 5412098 (1995-05-01), Yasuhiro et al.
patent: 5457104 (1995-10-01), Bartel et al.
patent: 5464796 (1995-11-01), Petersen et al.
patent: 5480879 (1996-01-01), Petersen et al.
patent: 5519016 (1996-05-01), Kimura et al.
patent: 5547962 (1996-08-01), Ito et al.
patent: 5556979 (1996-09-01), Philipps
patent: 5563155 (1996-10-01), Domagala et al.
patent: 5580872 (1996-12-01), Chu et al.
patent: 5599816 (1997-02-01), Chu et al.
patent: 5648567 (1997-07-01), Marhold et al.
patent: 5656623 (1997-08-01), White et al.
patent: 5726182 (1998-03-01), Chu et al.
patent: 5770597 (1998-06-01), Kim et al.
patent: 6235751 (2001-05-01), Park et al.
patent: 6329391 (2001-12-01), Ledoussal et al.
patent: 6387928 (2002-05-01), Ledoussal et al.
patent: 6645981 (2003-11-01), Ledoussal et al.
patent: 6849740 (2005-02-01), Ledoussal et al.
patent: 6900224 (2005-05-01), Ledoussal et al.
patent: 2073993 (1993-01-01), None
patent: 2152828 (1994-07-01), None
patent: 2212007 (1994-07-01), None
patent: 2212226 (1995-10-01), None
patent: 2217164 (1996-10-01), None
patent: 2238765 (1997-05-01), None
patent: 2228536 (1998-08-01), None
patent: 9201901 (1993-01-01), None
patent: 9302001 (1994-04-01), None
patent: 9400100 (1995-03-01), None
patent: 0106489 (1984-04-01), None
patent: 0195841 (1986-01-01), None
patent: 0195316 (1986-09-01), None
patent: 207 497 (1987-01-01), None
patent: 230 295 (1987-07-01), None
patent: 235 762 (1987-09-01), None
patent: 237 955 (1987-09-01), None
patent: 0308019 (1989-03-01), None
patent: 0342675 (1989-11-01), None
patent: 366 189 (1990-05-01), None
patent: 0366189 (1990-05-01), None
patent: 0413455 (1991-02-01), None
patent: 443 498 (1991-08-01), None
patent: 500 016 (1993-07-01), None
patent: 0550016 (1993-07-01), None
patent: 0572259 (1993-12-01), None
patent: 641 793 (1995-03-01), None
patent: 0775702 (1997-05-01), None
patent: 0947513 (1999-10-01), None
patent: 219910 (1993-03-01), None
patent: 1 279 532 (1997-01-01), None
patent: 51-086476 (1976-07-01), None
patent: 61-205258 (1986-09-01), None
patent: 61-225181 (1986-10-01), None
patent: 056673 (1987-08-01), None
patent: 62-255482 (1987-11-01), None
patent: 64-016767 (1989-01-01), None
patent: 03-115277 (1991-05-01), None
patent: 244733 (1991-08-01), None
patent: 05-112554 (1993-05-01), None
patent: 05-345777 (1993-12-01), None
patent: 09-002953 (1997-01-01), None
patent: 07-48367 (1997-02-01), None
patent: 09-052893 (1997-02-01), None
patent: 287669 (1997-04-01), None
patent: 09-136886 (1997-05-01), None
patent: 178847 (1997-06-01), None
patent: 240318 (1997-08-01), None
patent: 3745433 (2006-02-01), None
patent: 91/16894 (1991-11-01), None
patent: 95/10519 (1995-04-01), None
patent: 96/39407 (1996-12-01), None
patent: WO 97/19072 (1997-05-01), None
patent: WO 97/29102 (1997-08-01), None
patent: 98/52939 (1998-11-01), None
patent: 98/54169 (1998-12-01), None
patent: 99/07696 (1999-02-01), None
patent: WO 99/14214 (1999-03-01), None
patent: 00/21952 (2000-04-01), None
patent: 00/78748 (2000-12-01), None
patent: 01/53273 (2001-07-01), None
patent: 02/48138 (2002-06-01), None
Albrecht, “Development of Antibacterial Agents of the Nalidixic Acid Type”, Prog. In Drug Research, 21 (1977) pp. 9-104.
Koga et al., “Structure-Activity Relationships of Antibacterial 6,70-- and 7,8-Disubstituted 1-Alky1-1,4-dihyro-4-oxoquinoline-3carboxylic Acids”, J. Med. Chem., 23(1980), pp. 1358-1363.
Klopman et al., “Computer Automated Structure Evaluation of Uinolong Antibacterial Agents”, Antimicrob. Agents Chemother., 31(1987), pp. 1831-1840.
Wolfson et al., “The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Specra of Activity In Vitro”, Antimicrob. Agents Chemother. 28(1985), pp. 581-586.
Wentland et al., “Chap. 15. Quinolone Antibacterial Agents”, Annual Reports in Medicinal Chemistry, 1986, pp. 145-154.
Cornett et al., “Chap. 14. Quinolone Antibacterial Agents”, Annual Reports in Medicinal Chemistry, 1986, pp. 139-148.
Fernandes et al., “Chap. 12. Quinolones”, Annual Reports in Medicinal Chemistry, 1987, pp. 117-126.
Xiam et al., “Synthesis and in Vitro Antibacterial Activity of Some 1-(Difluoromethoxyphenyl) quinolone-3-carboxylic Acids”, J. Pharm. Sciences 78(1989). pp. 585-588.
Domagala et al., “7-Substituted 5-Amino-1 cyclopropyl-6,8-difluoro- 1,4-dihydro-4oxo3-quinolinecarboxylic Acids: Synthesis and Biological Activity of a New Class of Quinolone Antibacterials,” J. Med. Chem. 31(1988), pp. 503-506.
Sanchez et al., “Quinolone Antibacterial Agents. Synthesis and Structure-Activity Relationships of 8-Substituted Quinoline-3-carboxylic Acids and 1,8 Naphthyridine-3-carboxylic Acids,” J. Med. Chem. 31(1988), pp. 983-991.
Domagala et al., “1-Substituted 7-[3-[Ethylamino)methyl}-1 pyrrolidinyl} -6,8-difluoro-1, 4-dihyro-4oxo-3-quinoline carboyxlylic Acids. New Quantitative Structure-Activity Relationships at N 1 for the Quinolone Antibacterials”, J. Med. Chem., 31(1988), pp. 991-1001.
Rosen et al., “Asymmetric Synthesis and Properties of the Enantiomers of the Antibacterial Agent 7-(3-Aminopyrrolidin-l-yl)-1-(2,4-difluorophenyl)-1,4-dihyro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Hydrochloride”, J. Med. Chem. 31(1988), pp. 1586-90.
Rosen et al., “Desing, Synthesis, and Properties of (4S)-7-4(4Amino-2substituted-pyrrolidin l-yl) quinolone-3-carboxylic Acids”, J. Med. Chem., 31(1988), pp. 1598-1611.
Bouzard et al., “Fluoronaphthyridines and Quinolones as Antibacterial Agents. 1. Synthesis and Structure-Activity Relationships of New 1-Substituted Derivates”, J. Med. Chem. 32(1989), pp. 537-542.
Ledoussal et al., “Potent Non-6-fluoro-Substituted Quinolone Antibacterials: Synthesis and Biological Activitiy”, J. Med. Chem., 35(1992), pp. 198-200.
Domagala et al., “Quinolone Antibacterials Containing the New 7-[3-(1-aminoethyl)-1 pyrrolidinyl] Side Chain: The Effects of the 1-Aminoethyl Moiety and its Stereochemical Configurations on Potency and in Vivo Efficacy”, J. Med. Chem., 36(1993), pp. 871-882.
Hagen et al., “Synthesis and Antibacterial Activity of New Quinolones Containing a 7-[3-(1-Amino-1-methylethyl)-1-pyrrolidinyl] Moiety. Gram-Positive Agents with Excellent Oral Activity and Low Side-Effect Potential”, J. Med. Chem. 37(1994), pp. 733-738.
Cecchetti et al., “Studies on 6-Aminoquinolones: Synthesis and Antibacterial Evaluation of 6-Amino-8-methylquinolones”, J. Med. Chem.,, 39(1996), pp. 436-445.
Cecchetti et al, “Potent 6-Desluoro-8-methylq

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