Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-05-24
1998-09-01
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424423, 424424, 424426, 424427, 424430, 424434, 424437, 424489, 424490, A61K 950, A61K 914
Patent
active
058008292
ABSTRACT:
A method of making an immunoisolatory vehicle comprised of a core comprising living cells dispersed in a biocompatible matrix is disclosed, the cells being capable of secreting a biologically active product or of providing a metabolic or immunologic function to an individual, and an external jacket surrounding said core which is a biocompatible, permselective thermoplastic or hydrogel, said jacket being free of said cells, comprising coextruding a suspension comprising said cells dispersed in a precursor matrix material comprising extracellular matrix components or a biocompatible hydrogel precursor, and a solution of a biocompatible jacket precursor from a nested dual-bore extrusion nozzle, wherein the suspension of (a) is coextruded from the inner bore and the solution of (b) is coextruded from the outer bore of the nozzle, to form said jacket as the solution of (b) and the suspension of (a) arc coextruded; and exposing the vehicle to a treatment that forms a core comprising a volume of at least 1 .mu.l and at least 10.sup.4 cells and comprising a biocompatible matrix from the precursor matrix of solution (a).
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Aebischer Patrick
Christenson Lisa
Dionne Keith E.
Emerich Dwaine F.
Gentile Frank T.
Bawa Raj
Brown University Research Foundation
Elrifi Ivor R.
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