Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1994-04-22
1998-09-01
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
5303871, 5303879, 53038626, 53028885, 530324, 514 44, 514 12, 43524027, 4241451, 4241851, A61K 39395, A61K 3800
Patent
active
058008144
ABSTRACT:
Human procathepsin D was demonstrated to be mitogenic for breast cancer cells but not normal cells. The activation peptide of the procathepsin D appears to be responsible, since inhibition of enhancement of proliferation of breast cancer cells can be obtained by inhibition of the activation peptide through the use of an agent such as an antibody immunoreactive with the activation peptide.
REFERENCES:
Baldwin, E.T., "Crystal Structures of Native and Inhibited Forms of Human Cathepsin D: Implications for lysosomal Targeting and Drug Design," Proc. Natl. Acad. Sci. USA, vol. 90, pp. 6796-6800 (1993).
BarRett, A.J. "Purification of Isoenzymes from Human and Chicken Liver," Biochem J., vol. 117, pp. 601-607 (1970).
Bond, J.S., et al., "Intracellular Proteases," Ann. Rev. Biochem., vol. 56, pp. 333-364 (1987).
Cavailles, V., et al., "Cathepsin D Gene is Controlled by a Mixed Promoter, and Estrogens Stimulate only TATA-Dependent Transcription in Breast Cancer Cells," Proc. Natl. Acad. Sci. USA, vol. 90, pp. 203-207 (1993).
Clackson, T., et al., "Making Antibody Fragments Using Phage Display Libraries," Nature, vol. 352, pp. 624-628 (1991).
Creek, K.E., et al., "The Role of the Phosphomannosyl Receptor in the Transport of Acid Hydrolases to Lysosomes," Lysosomes in Biology and Pathology, pp. 63-82 (1984).
Daugherty, B.L., et al., "Polymerase Chain Reaction Facilitates the Cloning, CDR-grating, and Rapid Expression of a Murine Monoclonal Antibody Directed Against the CD18 Component of Leukocyte Integrins," Nucleic Acids Res., vol. 19, No. 9, pp. 2471-2476 (1991).
Diment, S., et al., "Cathespin D is Membrane-Associated in Macrophase Endosomes," J. Biological Chemistry, vol. 263, No. 14, pp. 6901-6907 (1988).
Eddy, A., et al., "The Distribution of the CR3 Receptor on Human Cells and Tissue as Revealed by a mOnoclonal Antibody," Clinical Immunology and Immunopathology, vol. 31, pp. 371-389 (1984).
Elangovan, S., et al., "Progesterone and Estrogen Control of Rates of Synthesis of Uterine Cathespin D," J. Biological Chemistry, vol. 255, No. 15, pp. 7474-7479 (1980).
Fusek, Martin, et al., "Mitogenic function of human procathepsin D: the role of the propeptide", Biochem., J., vol. 303:775-780 (1994).
Glickman, J.N., et al., "Manose 6-Phosphate-Independent Targeting of Lysosomal Enzymemes in I-Cell Disease B Lymophoblasts," J. Cell Biology, vol. 123, No. 1, pp. 99-108 (1993).
Grassel, S. et al., "Human Cathepsin D Precursor is Associated with a 60 kDa Glycosylated Polypeptide," Biochemical and Biophysical Research Communications, vol. 182, No. 1, pp. 276-282 (1992).
Grinstein S., et al., "Chemoattractant-Induced Tyrosine Phosphorylation and Activation of Microtuble-Associated Protein Kinase in Human Neutrophils." J. Biol. Chem., vol. 267, No. 25, pp. 18122-18125 (1992).
Hasilik, A., "The Early and Late Processing of Lysosomal Enzymes: Proteolysis and Compartmentation," Experientia 48 Birkhauser Veerlag, CH-=4010 Basel/Swizerland (1992).
Helminen, H.J., et al., "Quantitation of Lysosomal Enzyme Changes During Enforced Mdammary Gland Involution," Exptl. Cell Res. vol. 60, pp. 419-426 (1970).
Hoover, et al., Isolation of a Human Endothelial Cell Line from a Hepatic Angiocarcinoma, In Vitro 29A, 199-202 (1993).
Johnson, M.D., et al., "The Role of Cathespin D in the Invasiveness of Human Breach Cancer Cells," Cancer Research, vol. 53, pp. 873-877 (1993).
Kabat, H.A., et al., "Sequences of Proteins of Immunological Interest," 4th ed. (U.S. Dept. Health & Human Services, Bethesda, MD, 1987)*.
Kasai, M., et al., "Proenzyme Form of Cathepsin L Produced by Thymic Epithelial Cells Promotes Proliferation of Immature Thymocytes in the Presence of IL-1, IL-7, and Anti-CD3 Antibody," Cellular Immunology, vol. 150, pp. 124-136 (1993).
Klionsky, D.J. et al., "Intracellular Sorting and Processing of a Yeast Vacuolar Hydrolase: Proteinase A Propeptide Contains Vacuolar Targeting Information," Molecular and Cellular Biology, Vo. 8, No. 5, pp. 2105-2116 (1988).
Kornfeld, S., "Trafficking of Lysosomal Enzymes," FASEB J., vol. 1, pp. 462-468 (1987).
Kornfeld, S., "The Biogenesis of Lysosomes," Ann. Rev. Cell Biol., vol. 5, pp. 483-525 (1989).
Larsen, L.B., et al., "Procathepsin D Cannot Autoactivate to Cathepsin D at Acid pH," FEBS Letters, vol. 319, Nos. 1, 2, pp. 54-58 (1993).
Mathieu, M., et al., "Interactions of Cathepsin-D and Insulin-Like Growth Factor II (IGF-II) on the IGF-II/Mannose-6-Phosphate Receptor in Human Breast Cancer Cells and Possible Consequences on Mitogenic Activity of IGF-II)," Mol. Endo., vol. 4, No. 9, pp. 1327-1335 (1990).
McIntyre, G.F., et al., "The Lysosomal Proenzyme Receptor that Binds Procathepsin L to Microsomal Membranes at pH 5 is a 43-kDa Integral Membrane Protein," Proc. Natl. Acad. Sci. USA, vol. 90, pp. 10588-10592 (1993).
McIntyre, G.F., et al., "The pH-Dependent Membrane Association of Procathepsin L is Mediated by a 9-Residue Sequence within the Propeptide," J. Biological Chemistry, vol. 269, No. 1, pp. 567-572 (1994).
McIntyre, G.F., "Procathepsins L and D are Membrane-Bound in Acidic Microsomal Vesicles," J. Biological Chemistry, vol. 266, No. 23, pp. 15438-15445 (1991).
Metcalf, P., et al., Two Crystal Structures for Cathepsin D: the Isysosomal Targeting Signal and Active Site, The EMBO J., vol. 12, No. 4, pp. 1293-1302 (1993).
Morgan, D.O., et al., "Insulin-Like Growth Factor II Receptor as Multifunctional Binding Protein," Nature, vol. 329, pp. 301-307 (1987).
Myones, B.L., "Neutrophil and Monocyte Cell Surface p150.95 Has iC3b-Receptor (CR.sub.4), Activity Resembling CR.sub.3," J. Clin. Invest., vol. 82, pp. 640-651 (1988).
Rijnboutt, S., et al., "Mannose 6-Phosphate-Independent Membrane Association of Cathepsin D., Glucocerebrosidase, and Spingolipid-Activating Protein in HepG2 Cells," J. Biological Chemistry, vol. 266, No. 8, pp. 4862-4868 (1991).
Rochefort, H., "Biological and Clinical Significance of Cathepsin D in Breast Center," Acta Oncologica, vol. 31, No. 2, pp. 125-130 (1992).
Ross, G.S., et al., "Identification of a C3bi-Specific Membrane Complement Receptor that is Expressed on Lymphocytes, Monocytes, Neutrophils, and Erythrocytes," J. Exp. Med., vol. 155, pp. 96-110 (1982).
Sanchez, L.M., "Cathepsin D in Breast Secretions from Women with Breast Cancer," Br. J. Cancer vol. 67, pp. 1076-1081 (1993).
Stein, M., et al., "M, 46 000, Mannose 60-Phosphate Specific Receptor, Its Role in Targeting of Lysosomal Enzymes," The EMBO J. vol. 6, No. 9, pp. 2677-2681 (1987).
Vagner, J., et al., "Colour-Monitored Solid-Phase Multiple Peptide Synthesis under Low-Pressure Continuous-Flow Conditions, Synthesis of Medium-Size Peptides: The Propart of Human Procathepsin D and the Growth-Hormone Releasing Factor," Coll. Czech. Chem. Commun., vol. 58, pp. 435-444 (1993).
Vaupel, P., et al., "Blood Flow, Oxygen and Nutrient Supply, and Metabolic Microenvironment of Human Tumors: A Review," Cancer Research, vol. 49, pp. 6440-6465 (1989).
Vetvicka, et al., "Effect of human procathepsin D on proliferation of human cell lines," Cancer Letters, 79,:131-135 (1994).
Vetvicka, V., et al., "Complement Factors H and I Synthesize by B Cell Lines Function to Generate a Growth Factor Activity from C3.sup.1," J. Immunology, vol. 150, No. 9 (1993).
Vetvicka, V., et al., "Human Breast Milk Containing Procathepsin D-Detection by Specific Antibodies," Biochemistry and Molecular Biology International, vol. 30, No. 5, pp. 921-928 (1993).
Vignon, F., et al., "Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 53 K Protein," Endocrinology, vol. 118, No. 4, pp. 1537-1544 (1986).
von Figura, K., "Molecular Recognition and Targeting of Lysosomal Proteins," Current Opinion in Cell Biology, vol. 3, pp. 642-646 (1991).
Westley, B.R., et al., "Oestrogen Regulates Cathepsin D mRNA levels in Oestrogen Responsive Human Breast Cancer Cells," Nucleic Acids Research, vol. 15, No. 9, pp. 3773-3786 (1987).
Williams, K.P., et al., "Isolation of a Membrane-Associated Cathespin D-Like Enzyme from the Model Antigen Presenting Cell, A20, and its Ability to Generate Antigenic Fragment
Fusek Martin
Vetvicka Vaclav
Feisee Lila
Oklahoma Medical Research Foundation
Ungar Susan
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