Use of a partially neutralized, anionic (meth) acrylate...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C424S487000, C424S130100, C424S484000, C424S498000, C424S490000, C424S472000

Reexamination Certificate

active

07932258

ABSTRACT:
The invention relates to the use of a partially neutralized, anionic (meth)acrylate copolymer comprising radically polymerized units of 25 to 95 percent by weight of C1to C4alkyl esters of acrylic or methacrylic acid and 5 to 75 percent by weight of (meth)acrylate monomers with an anionic group, at least 4 percent of which are neutralized by means of a base, for producing a medicament that is provided with an active substance-containing core and is coated with the partially neutralized, anionic (meth)acrylate copolymer. The medicament releases at least 30 percent of the active substance contained therein in 30 minutes at a pH at which the active substance is sufficiently soluble and stable and at which the corresponding medicament that is coated with the non-neutralized anionic (meth)acrylate polymer releases less than 10 percent of the active substance contained therein.

REFERENCES:
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Gupta et al., “A novel pH—and time-based multi-unit potential colonic drug delivery system. I. Development,” International Journal of Pharmaceutics 213 (2001) 83-91.
U.S. Appl. No. 11/815,632, filed Aug. 6, 2007, Lizio, et al.
U.S. Appl. No. 60/908,855, filed Mar. 29, 2007, Lizio, et al.
U.S. Appl. No. 11/780,915, filed Jul. 20, 2007, Lizio, et al.
U.S. Appl. No. 12/598,138, filed Oct. 29, 2009, Liu, et al.

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