Compounds and pharmaceutical compositions for the treatment...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S043000, C544S243000, C544S256000, C544S317000

Reexamination Certificate

active

07951789

ABSTRACT:
Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

REFERENCES:
patent: 3480613 (1969-11-01), Walton
patent: 5627185 (1997-05-01), Gosselin et al.
patent: 6555676 (2003-04-01), Gosselin et al.
patent: 6653296 (2003-11-01), Holy et al.
patent: 6660721 (2003-12-01), Devos et al.
patent: 6752981 (2004-06-01), Erion et al.
patent: 6777395 (2004-08-01), Bhat et al.
patent: 6784166 (2004-08-01), Devos et al.
patent: 6787526 (2004-09-01), Bryant et al.
patent: 6812219 (2004-11-01), LaColla et al.
patent: 6846810 (2005-01-01), Martin et al.
patent: 6849726 (2005-02-01), Usman et al.
patent: 6852535 (2005-02-01), Thompson
patent: 6914054 (2005-07-01), Sommadossi et al.
patent: 6927291 (2005-08-01), Jin et al.
patent: 6984634 (2006-01-01), Cundy et al.
patent: 7022828 (2006-04-01), McSwiggen
patent: 7034009 (2006-04-01), Pavco et al.
patent: 7041817 (2006-05-01), Usman et al.
patent: 7094770 (2006-08-01), Watanabe et al.
patent: 7101861 (2006-09-01), Sommadossi et al.
patent: 7105493 (2006-09-01), Sommadossi et al.
patent: 7105499 (2006-09-01), Carroll et al.
patent: 7109165 (2006-09-01), Matulic-Adamic et al.
patent: 7125855 (2006-10-01), Bhat et al.
patent: 7144877 (2006-12-01), Gallop et al.
patent: 7157441 (2007-01-01), Sommadossi et al.
patent: 7176304 (2007-02-01), McSwiggen et al.
patent: 7202224 (2007-04-01), Eldrup et al.
patent: 2003/0060400 (2003-03-01), LaColla
patent: 2003/0219727 (2003-11-01), Becker et al.
patent: 2004/0023901 (2004-02-01), Cook
patent: 2004/0063658 (2004-04-01), Roberts et al.
patent: 2004/0121980 (2004-06-01), Martin et al.
patent: 2004/0209831 (2004-10-01), McSwiggen et al.
patent: 2004/0229839 (2004-11-01), Babu et al.
patent: 2004/0229840 (2004-11-01), Bhat et al.
patent: 2005/0009737 (2005-01-01), Clark
patent: 2005/0038240 (2005-02-01), Connolly et al.
patent: 2005/0182252 (2005-08-01), Reddy et al.
patent: 2005/0191302 (2005-09-01), Arthur et al.
patent: 2005/0203243 (2005-09-01), Polus
patent: 2005/0215510 (2005-09-01), Roberts et al.
patent: 2006/0040890 (2006-02-01), Martin et al.
patent: 2006/0046980 (2006-03-01), Erion et al.
patent: 2006/0111324 (2006-05-01), Choi et al.
patent: 2006/0234962 (2006-10-01), Olsen et al.
patent: 2006/0286615 (2006-12-01), Lederkremer et al.
patent: 2007/0037221 (2007-02-01), Block et al.
patent: 2007/0037735 (2007-02-01), Gosselin et al.
patent: 2007/0042939 (2007-02-01), LaColla
patent: 2007/0042940 (2007-02-01), LaColla et al.
patent: 2007/0042990 (2007-02-01), Gosselin et al.
patent: 2007/0042991 (2007-02-01), LaColla et al.
patent: 2007/0060498 (2007-03-01), Gosselin et al.
patent: 2007/0060503 (2007-03-01), Gosselin et al.
patent: 2007/0060504 (2007-03-01), Gosselin et al.
patent: 2007/0060505 (2007-03-01), Gosselin et al.
patent: 2007/0060541 (2007-03-01), Gosselin et al.
patent: 2007/0087960 (2007-04-01), Storer et al.
patent: 2008/0261913 (2008-10-01), Sommadossi et al.
patent: 101333235 (2008-12-01), None
patent: 1655033 (2006-10-01), None
patent: WO 88/00201 (1988-01-01), None
patent: WO 98/53813 (1998-12-01), None
patent: WO 01/32153 (2001-05-01), None
patent: WO 01/60315 (2001-08-01), None
patent: WO 01/79246 (2001-10-01), None
patent: WO 01/90121 (2001-11-01), None
patent: WO 01/92282 (2001-12-01), None
patent: WO 02/18404 (2002-03-01), None
patent: WO 02/32920 (2002-04-01), None
patent: WO 02/48165 (2002-06-01), None
patent: WO 02/057287 (2002-07-01), None
patent: WO 02/057425 (2002-07-01), None
patent: WO 03/062256 (2003-07-01), None
patent: WO 03/070750 (2003-08-01), None
patent: WO 03/105770 (2003-12-01), None
patent: WO 2004/002422 (2004-01-01), None
patent: WO 2004/002999 (2004-01-01), None
patent: WO 2004/003000 (2004-01-01), None
patent: WO 2004/003138 (2004-01-01), None
patent: WO 2004/009020 (2004-01-01), None
patent: WO 2004/022999 (2004-03-01), None
patent: WO 2004/072090 (2004-08-01), None
patent: WO 2004/096233 (2004-11-01), None
patent: WO 2004/096234 (2004-11-01), None
patent: WO 2004/096237 (2004-11-01), None
patent: WO 2004/096285 (2004-11-01), None
patent: WO 2004/096286 (2004-11-01), None
patent: WO 2004/096287 (2004-11-01), None
patent: WO 2004/100960 (2004-11-01), None
patent: WO 2004/000858 (2004-12-01), None
patent: WO 2005/012525 (2005-02-01), None
patent: WO 2005/021568 (2005-03-01), None
patent: WO 2005/021568 (2005-03-01), None
patent: WO 2005/044279 (2005-05-01), None
patent: WO 2005/044308 (2005-05-01), None
patent: WO 2005/087788 (2005-09-01), None
patent: WO 2006/012078 (2006-02-01), None
patent: WO 2006/012440 (2006-02-01), None
patent: WO 2006/116557 (2006-02-01), None
patent: WO 2006/063149 (2006-06-01), None
patent: WO 2006/093987 (2006-09-01), None
patent: WO 2006/094347 (2006-09-01), None
patent: WO 2006/116512 (2006-11-01), None
patent: WO 2007/020193 (2007-02-01), None
patent: WO 2007/095269 (2007-08-01), None
patent: WO 2008/062206 (2008-05-01), None
patent: WO 2008/082602 (2008-07-01), None
Egron et al., 2001, CAS: 136:20199.
Ballatore, et al., “Synthesis and Evaluation of Novel Amidate Prodrugs of PMEA and PMPA,” Bioorganic & Medicinal Chemistry Letters 11, 2001 1053-1056.
Beltran, et al., “Rational Design of a New Series of Pronucleotide,” Bioorganic & Medicinal Chemistry Letters, 11, 2001, 1775-1777.
Birkus, Cathepsin A Is the Major Hydrolase Catalyzing the Intracellular Hydrolysis of the Antiretroviral Nucleotide Phosphonoamidate Prodrugs GS-7340 and GS-9131, Antimicrobial Agents and Chemotherapy, 2007, 543-550.
Cahard, et al., “Aryloxy Phosphoramidate Triesters as Pro-Tides,” Mini-Reviews in Medicinal Chemistry, 2004, 4, 371-382.
Chapman, et al., “Practical Synthesis, Separation, and Stereochemical Assignment of the PMPA Pro-Drub GS-7340,” Nucleosides, Nucleotides & Nucleic Acids, 20(4-7), 621-628, 2001.
Chapman, et al., Purification of PMPA Amidate Prodrugs by SMB Chromatography and X-Ray Crystallography of the Diastereomerically Pure GS-7340, Nucleosides, Nucleotides & Nucleic Acids, 20(4-7), 1085-1090 , 2001.
Chou et al., “Phosphoramidate Pronucleotides: A Comparison of the Phosphoramidase Substrate Specificity of Human andEscherichia coliHistidine Triad Nucleotide Binding Proteins,” Molecular Pharmaceutics, vol. 4, No. 2, 208-217, 2006.
Drontle, et al., Designing a Pronucleotide Stratagem: Lessons from Amino Acid Phosphoramidates of Anticancer and Antiviral Pyrimidines, Mini-Reviews in Medicinal Chemistry, vol. 4, No. 4, 409-419, 2004.
Egron, et al., “S-Acyl-2-thioethyl Phosphoramidate Diester Derivatives as Mononucleotide Prodrugs,” J. Med. Chem., 46, 4564-4571, 2003.
Ergon , D.; Gosselin, G.; Bryant M.; Sommadossi J.-P.; Imbach J.-L., “Synthesis and study of antiviral S-acyl-2-thioethyl (SATE) phosphoramidate derivatives of b-L-ddA”, Antiviral Research, 2001, 50 (1), A45.
Egron, et al., “Synthesis and Anti-HIV Activity of Some S-Acyl-2-Thioethyl (SATE) Phosphoramidate Derivatives of 3′-Azido-2″,3″-Dideoxythymidine,” Nucleosides and Nucleotides, 18(4&5), 981-982, 1999.
Egron, “Synthesis and study of antiviral S-acyl-2-thioethyl (SATE) phosphoramidate derivatives of B-L-ddA.” Submitted for 14thInternational Conference on Antiviral Research, Seattle, WA; Apr. 8-13, 2001.
Egron, et al., “Synthesis and Study of a New Series of Phosphoramidate Derivatives as Mononucleotide Prodrugs,” Nucleosides, Nucleotides, 20(4-7), 751-754, 2001.
Eisenberg, et al., “Metabolism of GS-7340, A Novel Phenyl Monophosphoramidate Intracellular Prodrub of PMPA, in Blood,” Nucleosides, Nucleotides 20 (4-7), 1091-1098, 2001.
Erion, et al., “Targeting thyroid hormone receptor-B agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index,” PNAS, vol. 104, No. 39, 15490-15495, 2007.
Hecker, e

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