Process for preparation of enantiomerically pure esomeprazole

Details Process for preparation of enantiomerically pure esomeprazole Process for preparation of enantiomerically pure esomeprazole

2011-05-24

2011-05-24

Morris, Patricia (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07947840

ABSTRACT:
The present invention provides an improved and commercially viable process for preparation of substantially enantiomerically pure esomeprazole in neutral form or as a pharmaceutically acceptable salt or as its solvates including hydrates. Thus, for example, a compound containing a mixture of 1-(S)-camphorsulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole and 1-(S)-camphorsulfonyl-6-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole is hydrolyzed with barium hydroxide, isolated the resulting esomeprazole barium salt followed by neutralization with an acid to yield substantially enantiomerically pure esomeprazole in neutral form and then converted into its pharmaceutically acceptable salts.

REFERENCES:
patent: 9427988 (1994-12-01), None
patent: 02098423 (2002-12-01), None
patent: 2004002982 (2004-01-01), None
patent: 2004099181 (2004-11-01), None
patent: 2005105786 (2005-11-01), None
patent: 2006120520 (2006-11-01), None
patent: 2007013743 (2007-02-01), None

Affiliated with

Also associated with

Rating

Process for preparation of enantiomerically pure esomeprazole does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparation of enantiomerically pure esomeprazole, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparation of enantiomerically pure esomeprazole will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2664784