Diagnostic method for identifying carriers of the Marburg I...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S013000, C435S023000, C435S024000, C436S069000

Reexamination Certificate

active

07943333

ABSTRACT:
The present invention relates to a diagnostic method for identifying persons with genetically related hetero- or homozygous expression of the MR I variant of factor VII-activating protease (FSAP). The heterozygous or homozygous presence of an MR I polymorphism can be identified by a differential modulation of the FSAP activity.

REFERENCES:
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patent: 2002/0110552 (2002-08-01), Romisch et al.
patent: 2002/0142316 (2002-10-01), Roemisch et al.
patent: 2003/0124622 (2003-07-01), Roemisch et al.
patent: 2003/0215447 (2003-11-01), Roemisch et al.
patent: 2006/0045879 (2006-03-01), Althaus et al.
patent: 0 952 215 (1999-10-01), None
J. Roemisch et al., “The frequentMarburgI polymorphism impairs the pro-urokinase activating potency of the factor VII activating protease (FSAP),”Blood Coag. and Fibrinol., 13:433-441(2002).
J. Roemisch et al., “Quantitation of the Factor VII- and single-chain plasminogen activator-activating protease in plasmas of healthy subjects,”Blood Coag. and Fibrinol., 12: 375-383 (2001).
J. Roemisch et al., “Factor VII Activating Protease (FSAP): A Novel Protease in Hemostasis,”Biol. Chem., 383: 1119-1124 (2002).
J. Willeit et al., “Marburg I Polymorphism of Factor VII-Activating Protease: A Prominent Risk Predictor of Carotid Stenosis,”Circulation107: 667-670 (2003).
J. Romisch et al., “The FVII Activating Protease Cleaves Single-Chain Plasminogen Activators,”Haemostasis29: 292-299 (1999).
A. Hunfeld et al., “Detection of a Novel Plasma Serine Protease During Purification of Vitamin K-dependent Coagulation Factors,”FEBS Letters456: 290-294 (1999).

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