Induction of apoptosis by inhibition of sirtuin SIRT1...

Details Induction of apoptosis by inhibition of sirtuin SIRT1... Induction of apoptosis by inhibition of sirtuin SIRT1...

2011-01-04

2011-01-04

Bowman, Amy (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C514S04400A

Reexamination Certificate

active

07863436

ABSTRACT:
The invention relates to the induction of apoptosis by inhibition of the sirtuin SIRT1 expression, in particular the induction of apoptosis in tumour cells. Materials and methods for inhibiting SIRT1 expression are provided, including RNA interference methods. In particular, the invention provides a method of treating a proliferative disease comprising administering to an individual in need thereof an effective amount of a SIRT1 inhibitor.

REFERENCES:
patent: 2003/0082668 (2003-05-01), Tamai et al.
patent: 2003/0124101 (2003-07-01), Gu et al.
patent: 2005/0136429 (2005-06-01), Guarente et al.
patent: 01/51051 (2001-07-01), None
Scherer et al., Approaches for the sequence-specific knockdown of mRNA, 2003, Nat. Biotechnol., 21(12), pp. 1457-1465.
Mahato et al., Modulation of gene expression by antisense and antigene oligodeoxynucleotides and small interfering RNA, Jan. 2005, Expert Opinion on Drug Delivery, vol. 2, No. 1, pp. 3-28.
Zhang et al., Targeted Gene Silencing by Small Interfering RNA-Based Knock-Down Technology, 2004, Current Pharmaceutical Biotechnology, vol. 5, p. 1-7.
Grozinger et al., “Deacetylase enzymes: Biological functions and the use of small-molecule inhibitors”, Chemistry and Biology, vol. 9, No. 1, Jan. 2002, pp. 3-16, XP00233015.
International Search Report of PCT/GB2005/000459, mailed Jun. 14, 2005.
Grozinger et al., “Deacetylase enzymes: Biological functions and the use of small-molecule inhibitors”, Chemistry and Biology, vol. 9, No. 1, Jan. 2002, pp. 3-16, XP00233015.

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