Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing at least three carbocyclic rings
Reexamination Certificate
2011-07-05
2011-07-05
Tate, Chris R (Department: 1651)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing at least three carbocyclic rings
C435S004000, C435S283100, C435S369000, C435S371000
Reexamination Certificate
active
07972821
ABSTRACT:
A method for the production of functional proteins including hormones by renal cells in a three dimensional culturing process responsive to shear stress uses a rotating wall vessel. Natural mixture of renal cells expresses the enzyme 1-α-hydroxylase which can be used to generate the active form of vitamin D: 1,25-diOH vitamin D3. The fibroblast cultures and co-culture of renal cortical cells express the gene for erythropoietin and secrete erythropoietin into the culture supernatant. Other shear stress response genes are also modulated by shear stress, such as toxin receptors megalin and cubulin (gp280). Also provided is a method of treating an in-need individual with the functional proteins produced in a three dimensional co-culture process responsive to shear stress using a rotating wall vessel.
REFERENCES:
patent: 5153131 (1992-10-01), Wolf et al.
patent: 5153132 (1992-10-01), Goodwin et al.
patent: 5153133 (1992-10-01), Schwarz et al.
patent: 5155034 (1992-10-01), Wolf et al.
patent: 5155035 (1992-10-01), Schwarz et al.
patent: 5308764 (1994-05-01), Goodwin et al.
patent: 5496722 (1996-03-01), Goodwin et al.
patent: 5627021 (1997-05-01), Goodwin et al.
patent: 5637477 (1997-06-01), Spaulding et al.
patent: 5846807 (1998-12-01), Goodwin
patent: 5851816 (1998-12-01), Goodwin et al.
patent: 5858783 (1999-01-01), Goodwin et al.
patent: 5962324 (1999-10-01), O'Connor et al.
patent: 6117674 (2000-09-01), Goodwin et al.
patent: 6410320 (2002-06-01), Humes
patent: 6730498 (2004-05-01), Goodwin et al.
patent: 6946246 (2005-09-01), Goodwin et al.
patent: 7198947 (2007-04-01), Goodwin et al.
patent: 2003/0064503 (2003-04-01), Uemura et al.
patent: WO 95/11687 (1995-05-01), None
Goodwin et al., Rotating-Wall vessel coculture of small intestine as a prelude to tissue modeling: aspects of simulated microgravity, Feb. 1993,proc Soc Exp Biol Med, vol. 202, pp. 181-192.
Condamine et al., Local action of phosphate depletion and insulin-like growth factor 1 on in vitro production of 1, 25-dihydroxyvitamin D by cultured mammalian kidney cells, Oct. 1994, American Society for Clinical investigation, vol. 94, pp. 1673-1679.
Hough et al., Vitamin D Metabolism in the chronic streptozotocin-induced diabetic rat., 1983, Endocrinology, vol. 113, pp. 790-796.
Goodwin et al, Reduced Shear Stress: A Major Component in the Ability of Mammalian Tissues to Form Three-Dimensional Assemblies in Simulated Microgravity, Journal of Cellular Biochemistry, 51:301-311, 1993.
Jessup et al., Prospects for Use of Microgravity-Based Bioreactors to Study Three-Dimensional Host-Tumor Interactions in Human Neoplasia, Journal of Cellular Biochemistry, 52:290-300, 1993.
Spaulding et al., Advances in Cellular Construction, Journal of Cellular Biochemistry, 51:249-251, 1993.
Deluca, New Concepts of Vitamin D Functions, Annals New York Academy of Sciences; 669:59-69, 1992.
Hammond et al., Analysis and isolation of renal tubular cells by flow cytometry, Kidney International, 42:997-1005, 1992.
Hammond et al., Forward Scatter Pulse Width Signals Resolve Multiple Populations of Endosomes, Cytometry, 14:411-420, 1993.
Wolf et al., Analysis of Gravity-Induced Particle Motion and Fluid Perfusion Flow in the NASA-Designed Rotating Zero-Head-Space Tissue Culture Vessel, NASA Technical Paper 3143, 1991, pp. 1-12.
Moestrup et al., The Intrinsic Factor-Vitamin B12 Receptor and Target of Teratogenic Antibodies is a Megalin-binding Peripheral Membrane Protein with Homology to Developmental Proteins, Journal of Biological Chemistry, 273:5235-5242, 1998.
Resnick et al. Platelet-derived growth factor B chain promoter contains a cisacting fluid shear-stress-response element, Proc. Natl. Acad. Sci. USA 90: 4591-4595, May 1993.
Vats et al, “Stem Cells,” Lancet, Aug. 2005, vol. 366, pp. 592-602.
Poulsom et al, “Adult Stem Cell Plasticity,” Journal of Pathology, Jun. 2002, vol. 197, pp. 441-456.
Anglani et al, “In Search of Adult Renal Stem Cells,” Journal of Cellular and Molecular Medicine, 2004, vol. 8, No. 4, pp. 474-487.
Unsworth et al, “Growing Tissues in Microgravity,” Nature Medicine, Aug. 1998, vol. 4, No. 8, pp. 901-907.
Hammond et al, “Optimized suspension culture: the rotating-wall vessel,” American Journal of Physiology Renal Physiology, 2001, vol. 281, pp. F12-F25.
Antisense '97: A roundtable on the state of the industry. Nature Biotechnol. 15 (1997): 519-524.
Gewirtz et al. Facilitating oligonucleotide delivery: Helping antisense deliver on its promise. Proc. Natl. Acad. Sci. USA 93 (1996): 3161-3163.
Jen et al. Suppression of gene expression by targeted disruption of messenger RNA: Available options and current strategies. Stem Cells 18 (2000): 307-319.
Rojanasakul, Y. Antisense oligonucleotide therapeutics: Drug delivery and targeting. Adv. Drug Delivery Rev. 18(1996): 115-131.
Stull et al. Antigene, ribozyme, and aptamer nucleic acid drugs: Progress and prospects. Pharm. Res. 12(1995): 465-483.
J Ando et al., Jpn Heart J.,“Flow-dependent Regulation of Gene Expression in Vascular Endothelial Cells,” 1996-37:19-32.
Al-awqati et al., Stem cell in the kidney, Kidney International, 2002, vol. 61, pp. 387-395.
Khachigian et al., Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor N-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress., Aug. 1995, Journal of Clinical Investigation. vol. 96, pp. 1169-1175.
Vikas P. Sukatme, Early Transcriptional Events in Cell Growth; The Egr Family, 1990, Journal of The American Society of Nephrology, vol. 1, pp. 859-866.
James R. Woodgett, Fos and jun: two into one will go,1990, Seminars in Cancer Biology, vol. 1, pp. 389-397.
Schwarz et al., Cell culture for three-dimensional modeling in rotating-wall vessels; An application of simulated microgravity, 1992, journal of Tissue Culture Methods, vol. 14, pp. 51-57.
Roshak et al., Manipulation of disctinct NFkB proteins alters interleukin-1b-induced human rheumatoid synovial fibroblast prostaglandin E2 formation, Dec. 1996, The Journal of Biological Chemistry, vol. 271, pp. 31496-31501.
Alpers of al., Developmental patterns of PDGF B-chain, PDGF-receptor, and a-actin expression in human glomerulogenesis, Kidney International, 1992, vol. 42, pp. 390-399.
Ingram et al., Three-dimensional growth pattenrs of various human tumar cell lines in simulated microgravity o a NASA bioreactor, Jun. 1997, In Vitro Cellular & Developmental Biology—Animals, vol. 33, pp. 459-466.
ATCC Cell Lines and Hybridomas, 8th edition, p. 10, 1994.
Merriam-Webster “May” Merriam-Webster Online Dictionary, <URL: http://www.merriam-webster.com/dictionary/may>, 2008 (retrieved online Apr. 10, 2008), 2 pages.
Merriam-Webster “Might” Merriam-Webster Online Dictionary, <URL: http://www.merriam-webster.com/dictionary/may>, 2008 (retrieved online Apr. 10, 2008), 2 pages.
Goodwin Thomas John
Hammond Timothy Grant
Kaysen James Howard
Hammerle Kurt G.
Kosar Aaron
Tate Chris R
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