Medicinal composition for ophthal use containing acetylated...

Details Medicinal composition for ophthal use containing acetylated... Medicinal composition for ophthal use containing acetylated...

2011-05-17

2011-05-17

Olson, Eric S (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S062000, C536S123100, C536S119000

Reexamination Certificate

active

07943596

ABSTRACT:
The present invention provides an ophthalmic pharmaceutical composition containing acetylated hyaluronic acid and a pharmacologically acceptable carrier. Preferably, the average molecular weight of the acetylated hyaluronic acid is 10,000 to 1,000,000, and the acetyl group substitution number is from 2.0 to 4.0. In a preferred embodiment, this ophthalmic pharmaceutical composition is used in the treatment or prevention of dry eye, and in an even more preferred embodiment it is a dry-eye instillation.

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Merriam-Webster's Collegiate Dictionary, published 1998 by Merriam-Webster, incorporated, p. 924.
Oka, T., et al. “Differential scanning calorimetry studies on the mechanism of skin-softening effect of sodium acetylhyaluronate,” Polymer, 2000, pp. 6055-6059, vol. 41, Elsevier Science Ltd.
Oka, T., et al. “Skin-softening effect of acetylhyaluronate on stratum corneum,” Journal of Cosmetic Science, May/Jun. 1999, pp. 171-184, vol. 50.
Shimmura et al. British Journal of Ophthalmology (1995), vol. 79, pp. 1007-1077.

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