Method for testing substances on biomatrices

Details Method for testing substances on biomatrices Method for testing substances on biomatrices

2011-05-03

2011-05-03

Weber, Jon P (Department: 1657)

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

Reexamination Certificate

active

07935507

ABSTRACT:
The invention relates to a method for testing one or several substances. According to said method, a tissue equivalent is cultivated, the substance/s is/are made to affect the tissue equivalent, and it is determined whether the effect of the substance/s has resulted in a modification of the tissue equivalent and/or the substance/s. The tissue equivalent comprises at least one cell and a porous matrix based on a biologically compatible polymer or polymer mixture. The matrix is provided with pores having a maximum size of 150 μm as well as pores having a minimum size of 300 μm while the degree of porosity is 93 to 98 percent.

REFERENCES:
patent: 6103255 (2000-08-01), Levene et al.
patent: 2002/0094514 (2002-07-01), Bowlin et al.
patent: 2004/0063206 (2004-04-01), Rowley et al.
patent: 2007/0166343 (2007-07-01), Goerne et al.
patent: WO 98/44027 (1998-10-01), None
patent: WO 99/09149 (1999-02-01), None
patent: WO 01/87575 (2001-11-01), None
Kim et al. “Dynamic seeding and in vitro culture of hepatocytes in a flow perfusion system”, Tissue Engineering, 2000, 6(1):39-48.
Yoon et al. “Degradation behaviors of biodegradable macroporous scaffolds prepared by gas foaming of effervescent salts”, J biomed Mater Res. 2001, 55:401-408.
Qingpu Hou, et al., “Porous polymeric structures for tissue engineeriing prepared by a coagulation, compression moulding and salt leaching technique”, Biomaterials, XP004412414, vol. 24, No. 11, May 2003, pp. 1937-1947.
Leatrese D. Harris, et al., “Open pore biodegradable matrices formed with gas foaming”, Journal of Biomedical Materials Research, XP001021110, vol. 42, 1998, pp. 396-402.
Peter M. Kaufman, et al., Is there an Optimal Concentration of Cotransplanted Islets of Langerhans for Stimulation of Hepatocytes in Three Dimensional Matrices?, Transplantation, XP002369920, vol. 68, No. 2, Jul. 27, 1999, pp. 272-279.

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