Composition and method for enhancing immune response

Details Composition and method for enhancing immune response Composition and method for enhancing immune response

2011-04-19

2011-04-19

Li, Bao (Department: 1648)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C424S187100, C424S236100, C435S320100

Reexamination Certificate

active

07927833

ABSTRACT:
A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to an antigen. The adjuvant peptide is selected from a group of peptides with an HIV-related sequence. Additionally, the adjuvant peptide can comprise a fusion-protein that acts as a mucosal adjuvant. The adjuvant peptide can be transformed into one or more living cells, such that the mucosal adjuvant can be produced in living cells and then administered by systemic, mucosal or epidermal delivery.

REFERENCES:
patent: 5750332 (1998-05-01), Robey et al.
patent: 6258782 (2001-07-01), Barney et al.
patent: 6271198 (2001-08-01), Braisted et al.
Haddad et al. Eukaryotic cell 2002, vol. 1, No. 4, pp. 583-593.
Sirrangapatnam et al. Am J. Physiology 2007, vol. 293, C558-C565.
Backstrom et al., “Characterization of an internal permissive site in the cholera toxin B-subunit and insertion of epitopes from human immunodeficiency virus-I, hepatitis B virus and enterotoxigenicEscherichia coli.,” Gene, 165:163-171, 1995.
Backstrom et al., “Insertion of a HIV-1 neutralizing epitope in a surface-exposed internal region of the cholera-B subunit,”Gene, 149:211-217, 1994.
Coeffier et al., Antigenicity and immunogenicity of the HIV-1 gp41 epitope ELDKWA inserted into permissive sites of the MalE protein,Vaccine, 19:684-693, 2001.
Durrani et al. “Intranasal immunization with a plant virus expressing a peptide from HIV-1 gp41 stimulates better mucosal and systemic HIV-1-specific IgA and IgG than oral immunization,”J. Immunol. Methods, 93:93-103, 1998.
George-Chandy et al., “Cholera toxin B subunit as a carrier molecule promotes antigen presentation and increases CD40 and CD86 expression on antigen-presenting cells,”Infection and Immunity, 69(9):5716-5725, 2001.
Office Communication, issued in U.S. Appl. No. 10/506,796, dated Mar. 26, 2007.
Office Communication, issued in U.S. Appl. No. 10/506,796, dated Dec. 11, 2007.

Affiliated with

Also associated with

Rating

Composition and method for enhancing immune response does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Composition and method for enhancing immune response, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition and method for enhancing immune response will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2649717