Cyanopyridine derivative and use thereof as medicine

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S256000

Reexamination Certificate

active

07928126

ABSTRACT:
A therapeutic drug for cancer containing a substance selected from the group consisting of a novel cyanopyridine derivative, a pharmaceutically acceptable salt, a hydrate, a water adduct and a solvate as an active ingredient can be provided.

REFERENCES:
patent: 2005/0256102 (2005-11-01), Claiborne et al.
patent: 2002-95479 (2002-04-01), None
patent: 01/21595 (2001-03-01), None
patent: 02/22601 (2002-03-01), None
patent: 02/066461 (2002-08-01), None
patent: 03/055491 (2003-07-01), None
patent: 2005/013996 (2005-02-01), None
Vippagunta et al., “Crystalline Solid”, Advanced Drug Delivery Reviews 48 (2001) 3-26.
Guillory (in Brittain ed.), “Polymorphism, etc.,” NY: Marcel Dekker, Inc., 1999, 1-2, 183-226.
I. Melnikova et al., “Targeting Protein Kinases”, Nat. Rev. Drug Discovery, vol. 3, pp. 993-994, Dec. 2004.
D. M. Glover et al., “Mutations inauroraPrevent Centrosome Separation Leading to the formation of Monopolar Spindles”, Cell, vol. 81, pp. 95-105, Apr. 7, 1995.
D. Berdnik et al., “Drosophila Aurora-A is Required for Centrosome Maturation and Actin-Dependent Asymmetric Protein Localization During Mitosis”, Current Biology, vol. 12, pp. 640-647, Apr. 16, 2002.
H. Zhou et al., “Tumour Amplified Kinase STK15/BTAK Induces Centrosome Amplification, Aneuploidy and Transformation”, Nature Genetics, vol. 20, pp. 189-193, Oct. 20, 1998.
T. Tanaka et al., “Centrosomal Kinase AIK1 is Overexpressed in Invasive Ductal Carcinoma of the Breast”, Cancer Research, vol. 59, pp. 2041-2044, May 1, 1999.
C. Sakakura et al., “Tumour-Amplified Kinase BTAK is Amplified and Overexpressed in Gastric Cancers with Possible Involvement in Aneuploid Formation”, British Journal of Cancer, vol. 84, No. 6, pp. 824-831, 2001.
S. Sen et al., “Amplification/Overexpression of a Mitotic Kinase Gene in Human Bladder Cancer”, Journal of the National Cancer Institute, vol. 94, No. 17, pp. 1320-1329, Sep. 4, 2002.
D. Li et al., “Overexpression of Oncogenic STK15/BTAK/Aurora A Kinase in Human Pancreatic Cancer”, Clinical Cancer Research, vol. 9, pp. 991-997, Mar. 2003.
Y. M. Jeng et al., “Overexpression and Amplification of Aurora-A in Hepatocellular Carcinoma”, Clinical Cancer Research, vol. 10, pp. 2065-2071, Mar. 15, 2004.
S. Rojanala et al., “The Mitotic Serine Threonine Kinase,Aurora-2is a Potential Target for Drug Development in Human Pancreatic Cancer”, Molecular Cancer Therapeutics, vol. 3, No. 4, pp. 451-457, 2004.
J. R. Bischoff et al., “A Homologue ofDrosophila auroraKinase is Oncogenic and Amplified in Human Colorectal Cancers”, The EMBO Journal, vol. 17, No. 11, pp. 3052-3065, 1998.
E. A. Harrington et al., “VX-680, A Potent and Selective Small-Molecule Inhibitor of the Aurora Kinases, Suppresses Tumor Growth In Vitro”, Nature Medicine, vol. 10, No. 3, pp. 262-267, 2004.
N. Keen et al., “Aurora-Kinase Inhibitors as Anticancer Agents”, Nature Reviews Cancer, vol. 4, No. 12, pp. 927-936, Dec. 2004.
D. Fancelli et al., “Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition”, J. Med. Chem., vol. 48, pp. 3080-3084, 2005.
R. R. Adams et al., “Human INCENP Colocalizes with the Aurora-B/AIRK2 Kinase on Chromosomes and is Overexpressed in Tumor Cells”, Chromosoma, vol. 110, No. 2, pp. 65-74, 2001.
W. Fischle et al., “Regulation of HP1-Chromatin Binding by Histone H3 Methylation and Phosphorylation”, Nature, vol. 438, pp. 1116-1122, Dec. 2005.
T. Hirota et al., “Histone H3 Serine 10 Phosphorylation by Aurora B Causes HP1 Dissociation from Heterochromatin”, Nature, vol. 438, pp. 1176-1180, Dec. 2005.
J. J. Manfredi et al., “Taxol Binds to Cellular Microtubules”, The Journal of Biology, vol. 94, pp. 688-696, Sep. 1982.
I. Durko et al., “Effects of Two Microtubule-Depolymerizing Drugs, Vincristine and Vinblastine, on Porphyrin Production by Primary Neural Tissue Cultures” Neurochemical Research, vol. 15, No. 11, pp. 1135-1139, 1990.
P. B. Schiff et al., “Promotion of Microtubule Assembly In Vitro by Taxol”, Nature, vol. 277, pp. 665-667, 1979.
Chinese Office Action issued Mar. 10, 2010, in corresponding Chinese Application No. 2006800144518.4, with English translation.
Response to Chinese Office Action (2010), with English translation.

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