Metallocene-based chiral phosphine or arsine ligands

Details Metallocene-based chiral phosphine or arsine ligands Metallocene-based chiral phosphine or arsine ligands

2011-08-09

2011-08-09

Lee, Rip A. (Department: 1762)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C556S144000, C556S057000, C556S136000, C556S137000, C556S138000, C502S152000, C502S153000, C502S154000, C502S155000, C502S208000, C502S210000, C502S213000, C502S200000

Reexamination Certificate

active

07994355

ABSTRACT:
The present invention relates to metallocene-based phosphine ligands having chirality at phosphorus and at least one other element of chirality (planar chirality and/or chirality at carbon); and to the use of such ligands in asymmetric transformation reactions to generate high enantiomeric excesses of formed compounds. A method for the preparation of ligands according to the invention involving the conversion of the ortho-lithiated substituted metallocene to a phosphine chiral at phosphorus is also disclosed.

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