Oxazoloisoquinoline derivatives as thrombin receptor...

Details Oxazoloisoquinoline derivatives as thrombin receptor... Oxazoloisoquinoline derivatives as thrombin receptor...

2011-02-15

2011-02-15

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S089000

Reexamination Certificate

active

07888369

ABSTRACT:
This application provides for oxazolisoquinoline derivatives of the formulaor a pharmaceutically acceptable salt of said compoundwherein:B is —CH═CH—;M is —C(R1)(R2)—; andthe remaining substituents are as defined in the specification as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. This application also provides for combination therapy with the compounds of Ib or pharmaceutically acceptable salts thereof with other cardiovascular agents.

REFERENCES:
patent: 5362738 (1994-11-01), Burner et al.
patent: 5726182 (1998-03-01), Chu et al.
patent: 6063847 (2000-05-01), Chackalamannil et al.
patent: 6326380 (2001-12-01), Chackalamannil et al.
patent: 6433177 (2002-08-01), Bellani et al.
patent: 6645987 (2003-11-01), Chackalamannil et al.
patent: 7037920 (2006-05-01), Chackalamannil et al.
patent: 2001/0009916 (2001-07-01), Romero
patent: 2002/0045623 (2002-04-01), Charrier et al.
patent: 2004/0152736 (2004-08-01), Chackalamannil et al.
patent: WO 01/96330 (2001-12-01), None
Bensaid et al., “The Cannabinoid CB1Receptor Antagonist SR141716 Increases Acrp30 mRNA Expression in Adipose Tissue of Obese fa/fa Rats and in Cultured Adipocyte Cells”, Molecular Pharmacology, 63(4): 908-914 (2003).
Bernatowicz et al., “Development of Potent Thrombin Receptor Antagonist Peptides”,J. Med. Chem., 39: 4879-4887 (1996).
Chackalamannil, “A Highly Efficient Total Synthesis of (+)-Himbacine”,J. Am. Chem. Soc., 118: 9812-9813 (1996).
Pertwee, “Pharmacology of Cannabinoid Receptor Ligands”,Current Medicinal Chemistry, 6(8): 635-664 (1999).
International Search Report dated Dec. 5, 2007 for corresponding PCT Application No. PCT/US2006/048646.

Affiliated with

Also associated with

Rating

Oxazoloisoquinoline derivatives as thrombin receptor... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oxazoloisoquinoline derivatives as thrombin receptor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxazoloisoquinoline derivatives as thrombin receptor... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2637016