Methods for producing and using in vivo pseudotyped...

Details Methods for producing and using in vivo pseudotyped... Methods for producing and using in vivo pseudotyped...

2011-04-26

2011-04-26

Chen, Shin-Lin (Department: 1632)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Virus or bacteriophage

C424S093210, C435S235100, C435S455000

Reexamination Certificate

active

07931893

ABSTRACT:
The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. The present invention further relates to compositions for gene therapy.

REFERENCES:
patent: 5512421 (1996-04-01), Burns et al.
patent: 5643756 (1997-07-01), Kayman et al.
patent: 5654195 (1997-08-01), Sodroski et al.
patent: 5670354 (1997-09-01), Burns et al.
patent: 5693509 (1997-12-01), Cotten et al.
patent: 5711964 (1998-01-01), Dattagupta et al.
patent: 5739271 (1998-04-01), Sridhar et al.
patent: 6440730 (2002-08-01), Von Laer et al.
patent: 6531123 (2003-03-01), Chang
patent: 6555107 (2003-04-01), Poeschla et al.
patent: 6589763 (2003-07-01), Von Laer et al.
patent: 7135339 (2006-11-01), McCray, Jr. et al.
patent: 7160727 (2007-01-01), McCray et al.
patent: 2003/0054548 (2003-03-01), Kaleko et al.
patent: 2005/0112096 (2005-05-01), McCray, Jr. et al.
patent: 2005/0123517 (2005-06-01), McCray, Jr. et al.
patent: 1 006 196 (2000-06-01), None
patent: WO 98/44788 (1998-10-01), None
patent: WO 03/092582 (2003-11-01), None
International Search Report from PCT application serial No. PCT/US2004/39076, mailed Apr. 20, 2005.
Besnard et al., “Multiple interacting sites regulate astrocyte-specific transcription of the human gene for glial fibrillary acidic protein”,J Biol Chem, 266(28), 18877-18883 (1991).
Blömer et al., “Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector”,J Virol, 71(9), 6641-6649 (1997).
Brooks et al., “Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors”,PNAS, 99(9), 6216-6221 (2002).
Dylla et al., “Improved apical airway epithelia targeting properties of FIV vector pseudotyped with envelopes from LCMV”,Molecular Therapy, 9, Supplement 1, p. S186, abstract 491, (2004).
Loewen et al., “Transgene-specific toxicity in lentiviral vector-transduced feline TM in vivo”,ARVO Annual Meeting Abstract Search and Program Planner, abstract 1147, Annual Meeting of the Association for Research in Vision and Opthalmology, Fort Lauderdale, FL, USA, May 4-8, 2003 (2003).
Petreanu et al., “Maturation and death of adult-born olfactory bulb granule neurons: Role of olfaction”,J Neurosci, 22(14), 6106-6113 (2002).
Sinnayah et al., “Targeted viral delivery of Cre recombinase induces conditional gene deletion in cardiovascular circuits of the mouse brain”,Physiol Genomics, 18(1), 25-32 (2004).
Stein et al., “Gene transfer to the brain using feline immunodeficiency virus-based lentivirus vectors”,Methods Enzymol, 346, 433-454 (2002).
Stein et al., “The lymphocytic choriomeningitis virus envelope glycoprotein targets lentiviral gene transfer vector to neural progenitors in the murine brain”,Mol Ther, 11(3), 382-389 (2005).
Wichterle et al., “Direct evidence for homotypic, glia-independent neuronal migration”,Neuron, 18(5), 779-791 (1997).
Wong et al., “Transduction patterns of pseudotyped lentiviral vectors in the nervous system”,Mol Ther, 9(1), 101-111 (2004).
Azzouz et al., “Lentiviral vectors for treating and modeling human CNS disorders”,J Gene Med, 6(9), 951-962 (2004).
Burton et al., “Gene therapy progress and prospects: Parkinson's disease”,Gene Ther, 10(20), 1721-1727 (2003).
Hsich et al., “Critical issues in gene therapy for neurologic disease”,Hum Gene Ther, 13(5), 579-604 (2002).
Rainov et al., “Clinical trials with retrovirus mediated gene therapy—what have we learned?”,J Neurooncol, 65(3), 227-236 (2003).
Verma et al., “Gene therapy—promises, problems and prospects”,Nature, 389(6648), 239-242 (1997).
GenBank Accession No. V00878 dated Feb. 25, 2003.
Altschul et al., “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs,”Nucl. Acids. Res., 1997, 25 (17):3389-3402.
Altschul et al., “Basic Local Alignment Search Tool,”J. Mol. Biol., 1990, 215:403-410.
Alvarez-Buylla et al., “Identification of neural stem cells in the adult vertebrate brain,”Brain Res. Bull., 2002, 57(6):751-758.
Beyer et al., “Oncoretrovirus and Lentivirus Vectors Pseudotyped with Lymphocytic Choriomeningitis Virus Glycoprotein: Generation, Concentration, and Broad Host Range,”J. Virol., 2002, 76(3):1488-1495.
Beyer et al., “Recombinant Expression of Lymphocytic Choriomeningitis Virus Strain WE Glycoproteins: a Single Amino Acid Makes the Difference,”J. Virol., 2001, 75(2):1061-1064.
Boshart et al., “A Very Strong Enhancer Is Located Upstream of an Immediate Early Gene of Human Cytomegalovirus,”Cell, 1985, 41:521-530.
Buchmeier et al., “Arenaviridae: The Viruses and Their Replication,”Fields Virology, 4thed., 2001, Knipe and Howley (eds.), Lippincott Williams & Wilkins, vol. 2, pp. 1635-1668.
Burns et al., “Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells,”Proc. Natl. Acad. Sci. USA, 1993, 90:8033-8037.
Cao et al., “Identification of α-Dystroglycan as a Receptor for Lymphocytic Choriomeningitis Virus and Lassa Fever Virus,”Science, 1998, 282:2079-2081.
Chang et al., “Human Immunodeficiency Viruses Containing Heterologous Enhancer/Promoters Are Replication Competent and Exhibit Different Lymphocyte Tropisms,”J. Virol., 1993, 67:743-752.
Chen et al., “Generation of packaging cell lines for pseudotyped retroviral vectors of the G protein of vesicular stomatitis virus by using a modified tetracycline inducible system,”Proc. Natl. Acad. Sci. USA, 1996, 93:10057-10062.
Corpet et al., “Multiple sequence alignment with hierarchical clustering,”Nucl. Acids. Res., 1988, 16:10881-10891.
Culver et al., “Lymphocyte Gene Therapy,”Human Gene Ther., 1991, 2(2):107-109.
DePolo et al., “VSV-G Pseudotyped Lentiviral Vector Particles Produced in Human Cells Are Inactivated by Human Serum,”Mol. Ther., 2000, 2:218-222.
Dijkema et al., “Cloning and expression of the chromosomal immune interferon gene of the rat,”EMBO J., 1985, 4(3):761-767.
Doetsch et al., “Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain,”Cell, 1999, 97(6):703-716.
Doetsch et al., “Regeneration of a germinal layer in the adult mammalian brain,”Proc. Natl. Acad. Sci. USA, 1999, 96(20):11619-11624.
Duisit et al., “Five Recombinant Simian Immunodeficiency Virus Pseudotypes Lead to Exclusive Transduction of Retinal Pigmented Epithelium in Rat,”Mol. Ther., 2002, 6(4):446-454.
Gewirtz, “Oligodeoxynucleotide-Based Therapeutics for Human Leukemias,”Stem Cells, 1993, 11(Suppl. 3):96-103.
Goff, “Intracellular trafficking of retroviral genomes during the early phase of infection: viral exploitation of cellular pathways,”J. Gene Med., 2001, 3:517-528.
Gorman et al., “The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection,”Proc. Natl. Acad. Sci. USA, 1982, 79:6777-6781.
Grossman et al., “Successful ex vivo gene therapy directed to liver in a patient with familiar hypercholesterolaemia,”Nat. Genet., 1994, 6:335-341.
Henry and Campbell, “A Role for Dystroglycan in Basement Membrane Assembly,”Cell, 1998, 95:859-870.
Henry and Campbell, “Dystroglycan inside and out,”Curr. Opin. Cell Biol., 1999, 11:602-607.
Higgins and Sharp, “Fast and sensitive multiple sequence alignments on a microcomputer,”C

Affiliated with

Also associated with

Rating

Methods for producing and using in vivo pseudotyped... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for producing and using in vivo pseudotyped..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for producing and using in vivo pseudotyped... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2634240