Tuberculosis antigen detection assays and vaccines

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S023100, C536S024300, C536S024320, C530S300000, C530S350000, C424S009200, C424S184100, C424S190100, C424S234100, C424S248100

Reexamination Certificate

active

07968694

ABSTRACT:
The present invention relates to isolated Tuberculosis (TB) antigens that are useful in therapeutic and vaccine compositions for stimulating a TB specific immunological response. The identified antigens are also useful in diagnostic assays to determine the presence of active TB in an individual. Accordingly, the present invention includes polypeptide molecules, nucleic acid molecules, vaccine compositions, diagnostic assays, and methods of diagnosis and monitoring treatment related to these TB antigens.

REFERENCES:
patent: 6183957 (2001-02-01), Cole et al.
patent: 6294328 (2001-09-01), Fleischmann et al.
patent: 7026465 (2006-04-01), Skeiky et al.
patent: 7064195 (2006-06-01), Skeiky et al.
patent: WO 02/48175 (2002-06-01), None
patent: WO 03/004520 (2003-01-01), None
Mukherjee S,et al.,“Potential serological use of a recombinant protein that is a replica of aMycobacterium tuberculosisprotein found in the urine of infected mice”Clin Diagn Lab Immunol. 11(2):280-6 (2004).
Liu, C. et al., “Expression and purification of immunologically reactive DPPD, a recombinantMycobacterium tuberculosisskin test antigen, usingMycobacterium smegmatisandEscherichia colihost cells”Can J Microbiol. Feb;50(2):97-105 (2004).
Grobusch, Martin P. et al., “Rapid Immunochromatographic Assay for Diagnosis of Tuberculosis, Letter to the Editor”J Clin. Microb. 36(11):3443 (1998).
Mukherjee S. et al. “Alternative approach to expressMycobacterium tuberculosisproteins inEscherichia coli.” BiotechniquesJul;35(1):34-6, 38, 40. (2003).
Mukherjee S. et al. “Cloning of the gene encoding a protectiveMycobacterium tuberculosissecreted protein detected in vivo during the initial phases of the infectious process.”J Immunol. Oct 15;175(8):5298-305 (2005).
Fleischmann R.D. et al. “Whole-genome comparison ofMycobacterium tuberculosisclinical and laboratory strains.” Journal of Bacteriology. 184(19):5479-5490, (Oct. 2002).
Database Uniprot Phosphoribosylglycinamide formyltransferase 2, Acc. No. P95197, (May 1, 1997).
Flyer D. C. et al. “Identification by mass spectrometry of CD8+-T-cellMycobacterium tuberculosisepitopes within the Rv 0341 product.” Infection and Immunity, American Society for Microbiology. Washington, US. 70(6):2926-2932, (Jun. 2006).

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