2'-fluoro substituted carba-nucleoside analogs for antiviral...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S018700, C536S029200, C536S055000

Reexamination Certificate

active

07973013

ABSTRACT:
Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 2′ position of the nucleoside sugar is substituted with halogen and carbon substitutents. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections caused by both wild type and mutant strains of HCV.

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International Search Report for PCT/US2010/049471, mailed Nov. 18, 2010.
Written Opinion for PCT/US2010/049471, mailed Nov. 18, 2010.

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