Integrase cofactor

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Reexamination Certificate

active

08008470

ABSTRACT:
The present invention provides nucleic acid molecules which include a region specifically interacting with the nucleic acid encoding the LEDGF/P75 protein or the nucleic acid encoding a fragment of a LEDGF/P75 protein and methods and uses of such nucleic acid molecules.

REFERENCES:
patent: 5872213 (1999-02-01), Goff
patent: 6222024 (2001-04-01), Goff
patent: 6750052 (2004-06-01), Shinohara et al.
patent: 7326416 (2008-02-01), Kalpana
patent: 2004/0091487 (2004-05-01), Kalpana
patent: 2006/0034860 (2006-02-01), Legrain et al.
patent: 2006/0275748 (2006-12-01), Debyser et al.
patent: 2007/0259358 (2007-11-01), Debyser et al.
patent: WO 95/31904 (1995-11-01), None
patent: WO 99/05278 (1999-02-01), None
patent: WO 00/29578 (2000-05-01), None
Llano (J. Virol. 78(17): 9524-9537, 2004).
Vasquez et al (TIBS 23: 4-9, 1998).
Gryzanov (Biochim. Biophys. Acta 1489:131-140, 1999).
Agrawal et al (Mol. Med. Today 6:72-81, 2000).
Opalinska et al (Nature Reviews Drug Discovery, 2002, vol. 1, pp. 503-514).
Caplen (Expert Opin. Biol. Ther. 2003, vol. 3, pp. 575-586).
Check (Nature, 2003, vol. 425, pp. 10-12).
Scanlon (Curr. Pharm. Biotech. 5:415-420, 2004).
Cejka et al (Clinical Science 110: 47-58, 2006).
Grossman et al (Neuro-Oncology 6: 32-40, 2004).
Nguyen et al (Curr. Opin. Mol. Ther. 10(2): 158-167, 2008).
Moulder et al (Clin. Cancer Res. 14(23): 7909-7916, 2008).
Rudin et al (J. Clin. Oncol.26(6): 870-876, 2008).
Brodin et al., “Disruption of HIV-1 Integrase-DNA Complexes by Short 6-Oxocytosine-Containing Oligonucleotides,”Biochemistry41(5):1529-1538 (2002).
Cherepanov et al., “HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells,”J. Biol. Chem. 278(1):372-381 (2003).
Cherapanov et al., “Solution Structure of the HIV-1 Integrase Binding Domain in LEDGF/p75,”Nat. Struct. Mol. Biol. 12(6):526-532 (2005).
Dietz et al., “The Family of Hepatoma-Derived Growth Factor Proteins: Characterization of a New Member HRP-4 and Classification of its Subfamilies,”Biochem. J. 366(pt. 2):491-500 (2002).
Leh et al., “Determinants of Mg2+-Dependent Activities of Recombinant Human Immunodeficiency Virus Type 1 Integrase,”Biochemistry39(31):9285-9294 (2000).
Merriam-Webster's Online Dictionary, http://www.merriam-webster.com/cgi-bin/dictionary?book=Dictionary&va=analogue, accessed on Jul. 15, 2008; definition of analogue.
Ochs et al., “Autoantibodies to DFS 70 KD/transcription Coactivator p75 in Atopic Dermatitis and Other Conditions,”J. Allergy Clin. Immunol. 105(6 pt. 1):1211-1220 (2000).
Podtelezhnikov et al., “Modeling HIV-1 Integrase Complexes Based on Their Hydrodynamic Properties,”Biopolymers68(1):110-120 (2003).
Rahman et al., “Structure-Based Mutagenesis of the Integrase-LEDGF/p75 Interface Uncouples a Strict Correlation Between In Vitro Protein Binding and HIV-1 Fitness,”Virol. 357(1):79-90 (2007).
Sigma-Aldrich online catalog, <http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDetail/101739>, accessed on Jul. 15, 2008.
Vanegas et al., “Identification of the LEDGF/p75 HIV-1 Integrase-Interaction Domain and NLS Reveals NLS-Independent Chromatin Tethering,”J. Cell Sci. 118(pt. 8):1733-1743 (2005).
Van Gent et al., “DNA Binding Properties of the Integrase Proteins of Human Immunodeficiency Viruses Types 1 and 2,”Nucleic Acids Res. 19(14):3821-3827 (1991).
International Search Report for International Application PCT/BE2003/000164, mailed Jul. 1, 2004.
Restriction Requirement for U.S. Appl. No. 10/529,508, mailed Jan. 3, 2007.
Office Action for U.S. Appl. No. 10/529,508, mailed May 31, 2007.
Restriction Requirement for U.S. Appl. No. 11/675,507, mailed Apr. 10, 2008.
Office Action for U.S. Appl. No. 10/529,508, mailed Jun. 26, 2008.
Office Action for U.S. Appl. No. 11/675,507, mailed Aug. 5, 2008.
Notice of Allowance and Notice of Allowability for U.S. Appl. No. 10/529,508, mailed Nov. 25, 2008.

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