Human brain carboxypeptidase B

Details Human brain carboxypeptidase B Human brain carboxypeptidase B

2011-07-05

2011-07-05

Kolker, Daniel E (Department: 1649)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S024000, C435S183000, C424S094630

Reexamination Certificate

active

07972771

ABSTRACT:
A novel carboxypeptidase and the encoding gene thereof were successfully identified by screening a human hippocampus extract using brain-APP-cleaving activity as an index. This protein and its gene are useful in, for example, preventing, treating, examining, and diagnosing diseases that cause accumulation of Aβ in the brain, including senile dementia, Alzheimer's disease, Down's syndrome, hereditary cerebral hemorrhage, and cephalic contusion.

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