Modified carbocyanine dyes and their conjugates

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving fixed or stabilized – nonliving microorganism,...

Reexamination Certificate

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C436S086000, C436S094000, C530S402000, C536S055300, C548S491000, C548S465000, C548S159000, C548S427000, C546S113000, C546S115000, C546S083000

Reexamination Certificate

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07927830

ABSTRACT:
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

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