Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
1999-03-16
2001-02-20
Kishore, Gollamudi S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S049000, C424S059000, C424S063000, C424S064000, C424S069000, C424S070100, C424S070600, C424S070700, C514S506000, C514S844000, C514S865000, C514S846000, C514S847000, C514S880000, C514S881000
Reexamination Certificate
active
06190679
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to lysophospholipids for use in cosmetics having high storage stability and excellent in feeling upon use as well as to a cosmetic composition comprising the same.
BACKGROUND OF THE INVENTION
Phospholipid is known as a surface active agent or emulsifying agent which is mild to the skin. Lysophospholipid obtained by converting the phospholipid into its lyso form by enzyme treatment or the like means is also known as a surface active agent or emulsifying agent which is tender to the skin (JP-A-61-112007, JP-A-63-41411; the term “JP-A” as used herein means a “Japanese published unexamined patent application”). Examples of the known lysophospholipid include those which are produced from phospholipid of animal origin such as the egg yolk, bovine brain or swine brain or from phospholipid of plant origin such as soybean, corn, rapeseed or the like plant seed, and they are used in cosmetics, quasi drugs, toiletries and the like, as surface active agents, solubilizing agents, emulsifying agents, gelling agents, moisture-keeping agents or liposome-making agents.
Since lysophospholipid, when compounded in cosmetics, can provide the products with a soft touch, it is an effective material for improving the touch of products during and after their use.
However, since there are problems from the viewpoint of stability (such as odor and discoloration), there is a limitation, in terms of formulation designing such as blending amount and masking of an oxidized soybean-like odor. Although a hydrogenated lysolecithin is available (in which unsaturated fatty acids of lysophospholipid are hydrogenated) in order to improve stability, the material provides poor feel because of less adaptability and moist sensation on the skin.
The object of the present invention is to provide lysophospholipids for use in cosmetics having both high storage stability and excellent feeling upon use, a cosmetic composition comprising the same and methods using the lysophospholipid.
SUMMARY OF THE INVENTION
The inventors of the present invention have found that cosmetics having excellent stability and feeling upon use can be obtained by preparing cosmetic compositions with lysophospholipid obtained by converting high oleic phospholipid into its lyso form.
The present invention relates to the following (1) to (14).
(1) A composition comprising lysophospholipids, wherein at least 30 mol % of the fatty acids bonded to said lysophospholipids are monoenoic fatty acids.
(2) The composition according to (1), wherein at least 50 mol % of the fatty acids bonded to said lysophospholipids are monoenoic fatty acids.
(3) The composition according to (2), wherein at least 70 mol % of the fatty acids bonded to said lysophospholipids are monoenoic fatty acids.
(4) The composition according to any one of (1) to (3), wherein at most 20 mol % of the fatty acids bonded to said lysophospholipids are polyenoic fatty acids.
(5) The composition according to (4), wherein at most 15 mol % of the fatty acids bonded to said lysophospholipids are polyenoic fatty acids.
(6) The composition according to (5), wherein at most 10 mol % of the fatty acids bonded to said lysophospholipids are polyenoic fatty acids.
(7). The composition according to any one of (1) to (6), wherein said monoenoic fatty acids have 4-34 carbon atoms.
(8) The composition according to (7), wherein said monoenoic fatty acids have 14-24 carbon atoms.
(9) The composition according to any one of (1) to (8), wherein saturated fatty acids bonded to said lysophospholipids have 1-34 carbon atoms.
(10) The composition according to (9), wherein saturated fatty acids bonded to said lysophospholipids have 6-24 carbon atoms.
(11) A cosmetic composition, which comprises the composition according to any one of (1) to (10) and a cosmetically acceptable carrier.
(12) A method of improving storage stability in a cosmetic composition, which comprises the step of blending lysophospholipids according to any one of (1) to (10) into a cosmetic composition comprising cosmetically acceptable carrier, wherein said lysophospholipids are present in said cosmetic composition in a total amount of 0.01 to 99.99% by weight.
(13) A method of improving feeling upon use of a cosmetic composition, which comprises the step of blending lysophospholipids according to any one of (1) to (10) into a cosmetic composition comprising cosmetically acceptable carrier, wherein said lysophospholipids are present in said cosmetic composition in a total amount of 0.01 to 99.99% by weight.
(14) A method of providing suitable feeling upon use of a cosmetic composition, which comprises the step of applying lysophospholipids according to any one of (1) to (10) to the body, wherein said lysophospholipids are present in said cosmetic composition in a total amount of 0.01 to 99.99% by weight.
DETAILED DESCRIPTION OF THE INVENTION
The lysophospholipid of the present invention is glycerol-based. In this event, the lysophospholipid may be either 1-acyl-2-lysophospholipid or 2-acyl-1-lysophospholipid or a mixture thereof.
Kinds of the phospholipid are not particularly limited, and examples thereof include phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidic acid, phosphatidylglycerol, N-acylphosphatidylethanolamine, phosphatidylserine and the like which may be used alone or as a mixture thereof.
Preferred examples of the phospholipid to be used in the present invention include phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol and phosphatidic acid.
Regarding the fatty acids bonded to the lysophospholipid mixture, those in which 30 mol % or more of the total fatty acids are monoenoic fatty acids are desirable, 50 mol % or more are monoenoic fatty acids are more desirable and 70 mol % or more are monoenoic fatty acids are most desirable.
The remaining fatty acids are saturated fatty acids and polyenoic fatty acids. Regarding the fatty acids bonded to the lysophospholipid mixture to be used in the present invention, those in which 30 mol % or more of the total fatty acids are monoenoic fatty acids and the polyenoic fatty acid content is 20 mol % or less are desirable, 30 mol % or more of the total fatty acids are monoenoic fatty acids and the polyenoic fatty acid content is 15 mol % or less are more desirable and 30 mol % or more of the total fatty acids are monoenoic fatty acids and the polyenoic fatty acid content is 10 mol % or less are most desirable.
The monoenoic fatty acid is a fatty acid which has one double bond in the alkyl chain moiety of a saturated fatty acid. Though the number of its carbon atoms is not particularly limited, straight or branched monoenoic fatty acids having 4 to 34 carbon atoms can be exemplified, and monoenoic fatty acids having 14 to 24 carbon atoms are desirable. Illustrative examples of the monoenoic fatty acid include butenoic acid, pentenoic acid, hexenoic acid, heptenoic acid, octenoic acid, nonenoic acid, decenoic acid, undecenoic acid, dodecenoic acid, tridecenoic acid, tetradecenoic acid, pentadecenoic acid, hexadecenoic acid, heptadecenoic acid, octadecenoic acid, nonadecenoic acid, icosenoic acid, henicosenoic acid, docosenoic acid, tricosenoic acid, tetracosenoic acid, pentacosenoic acid, hexacosenoic acid, heptacosenoic acid, octacosenoic acid, nonacosenoic acid, triacontenoic acid, hentriacontenoic acid, dotriacontenoic acid, tritriacontenoic acid, tetratriacontenoic acid and the like.
The decenoic acid includes obtusilic acid and the like, the dodecenoic acid includes linderic acid and the like, the tetradecenoic acid includes tsuzuic acid and the like, the hexadecenoic acid includes palmitoleic acid and the like and the octadecenoic acid includes petroselinic acid, oleic acid, elaidic acid, vaccenic acid and the like.
Any fatty acid may be used as the monoenoic fatty acid, with the proviso that it has one double bond, and it may be used as a single monoenoic fatty acid or as a mixture of monoenoic fatty acids having different carbon numbers or, even in the case of the same number of carbon atoms, monoenoi
Matsuura Ichiro
Takekoshi Yoichiro
Fitzpatrick ,Cella, Harper & Scinto
Kishore Gollamudi S.
Kyowa Hakko Kogyo Co. Ltd.
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