Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1998-03-25
2000-05-16
Mertz, Prema
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
5303873, 536 231, 536 235, 536 243, 536 2431, 435 691, 435 697, C07K 1447, C12N 1512, C12N 1563, C12N 510
Patent
active
060639032
ABSTRACT:
Polypeptides which bind to one or more EPH-like receptors, particularly the HEK4 receptor, are described. The polypeptides are designated HEK4 binding proteins. Nucleic acids encoding HEK4 binding proteins, and expression vectors, host cells and processes for the production of the polypeptides are also described. The polypeptides are useful for modulating the growth and/or differentiation of a variety of tissues, including those from liver, kidney, lung, skin, digestive tract and nervous system and may be used to regenerate damaged or depleted tissue and to treat cancer or nervous system disorders.
REFERENCES:
George et al. Macromolecular Sequencing & Synthesis, pp. 127-149, Alan R. Liss Inc., 1988.
Cunningham et al. Science vol. 244, pp. 1081-1085, 1989.
Bartley et al. Nature 368, 558-560 (1994).
Becker et al. Mech. Dev. 47, 3-17 (1994).
Bennett et al. J. Biol. Chem. 269, 14211-14218 (1994).
Bohme et al. Oncogene 8, 2857-2862 (1993).
Chan and Watt, Oncogene 6, 1057-1061 (1991).
Cheng and Flanagan, Cell 79, 157-168 (1994).
Davis et al. Science 266, 816-819 (1994).
Ganju et al. Oncogene 9, 1613-1624 (1994).
Harlow and Lane, Antibodies: A laboratory Manual Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1988).
Hirai et al. Science 238, 1717-1725 (1987).
Holzman et al. Mol. Cell Biol. 10, 5830-5838 (1990).
Hunt et al. Exp. Hematol. 19, 779-784 (1991).
Kenney et al. in New Protein Techniques J. M. Walker, ed. The Human Press, Clifton, N.J. (1988).
Kozak, Cell 44, 283-292 (1986).
Lindberg et al., Mol. Cell. Biol. 10, 6316-6324 (1990).
Maisonpierre et al. Oncogene 8, 3277-3288 (1993).
Molecular Cloning, A Laboratory Manual, 2d ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1989).
Pasquale, Cell Regulation 2, 523-534 (1991).
Remington's Pharmaceutical Sciences 18th ed. A.R. Gennaro, ed. Mack, Easton, PA (1990).
Sajjadi and Pasquale, Oncogene 8, 1807-1813 (1993).
Sajjadi et al. The New Biologist 3, 769-778 (1991).
Van der Geer et al. Ann. Rev. Cell. Biol. 10, 251-337 (1994).
Wicks et al. PNAS 89, 1611-1615 (1992).
Yansura, Methods in Enzymology v. 185 D.V. Goeddel, ed. Academic Press, Inc., New York, pp. 161-166 (1990).
Bartley Timothy D.
Fox Gary M.
Amgen Inc.
Levy Ron K.
Mertz Prema
Odre Steve M.
Winter Robert B.
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