Transport protein which effects the transport of cationic xenobi

Details Transport protein which effects the transport of cationic xenobi Transport protein which effects the transport of cationic xenobi

1998-03-18

2000-05-16

Kemmerer, Elizabeth

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530350, A61K 3816, C07K 14435

Patent

active

060637668

ABSTRACT:
A transport protein has been cloned which is present in liver epithelial cells and kidney epithelial cells and in intestinal cells and is responsible for transporting cationic pharmaceuticals and/or xenobiotics. This transport protein has been described more specifically by its DNA and amino acid sequences, and various uses are disclosed which are, in particular, of great importance for developing novel medicaments.

REFERENCES:
Simonson et al., Molecular cloning and characterization of a novel liver-specific transport protein, Journal of Cell Science, vol. 107: 1065-1072 (1994).
Boerner et al., Polarity of neutral amino acid transport and characterization of a broad specificity transport activity in a kidney epithelial cell line, MDCK, The Journal of Biological Chemistry, vol. 261(30):13957-13962 (1986).
Grundemann et al., Drug excretion mediated by a new prototype of polyspecific transporter, Nature, vol. 372: 549-552 (1994).
George et al., Current Methods in Sequence Comparison and Analysis, Macromolecular Sequencing and Synthesis: Selected Methods and Applications, Schlesinger, ed., Alan R. Liss, Inc. NY, pp. 127-149 (1988).
Watson et al., Recombinant at the Molecular Level, Molecular Biology of the Gene, Benjamin/Cummings Publishing Co., Inc., Menlo Park, p. 313.
Bowie et al. Science 247:1306-1310, 1990.
Ngo et al. The Protein Folding Problem and Tertiary Structure Prediction, Merz et al., eds., Birkhauser, Boston, pp. 492-495, 1990.
Wells. Biochemistry 29:8509-8517, 1990.
Schulz et al. Principles of Protein Structure, Springer-Verlag, New York, pp. 14-16, 1979.

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