Cerebral vasodilating 6-substituted vincamines

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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546 51, C07D51904, A61K 31445

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active

041407776

ABSTRACT:
The invention relates to novel derivatives of vincamine and apovincamine having the formula ##STR1## WHICH ARE ENDOWED WITH ANALOGOUS PROPERTIES AS THE VINCAMINE AND APOVINCAMINE AS WELL AS WITH AN EXTENDED EFFECT. The invention relates also to the methods for the preparation of the above derivatives.

REFERENCES:
Wiberg, K. B. et al., (Ed), Oxidation in Organic Chemistry, part A, Academic Press, New York, 1965, pp. 105-106.
House, H. O.,Modern Synthetic Reactions, 2nd Ed., W. A. Benjamin, Inc., Menlo Park, Cal., 1972, pp. 49-51 (I) and 345-355 (II); 1st Ed., 1965, p. 31 (III).
Foerst, W., Newer Methods of Preparative Organic Chemistry, vol. IV, Academic Press, New York, 1968, pp. 224-227.
Fieser, L. F. et al., Reagents for Organic Synthesis, vol. 1, John Wiley and Sons, Inc., New York, 1965, p. 620.
House, H., Modern Synthetic Reactions, W. A. Benjamin, New York, 1965, p. 84.

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