Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Reexamination Certificate
1998-09-01
2001-10-30
Isabella, David J. (Department: 3738)
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
C514S012200, C128S898000
Reexamination Certificate
active
06309381
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to methods of treatment of acute myocardial infarction (AMI), in particular, treatment of AMI close to the onset in order to avoid most of the complications and the destructive race of cells and collagen framework which are linked to the AMI.
2. Description of the Related Art
For about thirty years, human growth hormone has been proposed as a possible treatment for various diseases and medical problems, such as to stimulate the fibroblasts; also to include neoangiogenesis. Efforts to reach profound degrees of experimental hibernation in animals only became possible when the threshold of ventricular fibrillation was raised through the use of human growth hormone.
More recently, other investigations with human growth hormone and isolated growth factors, (like IGF1; FGF and TGF) verified parallel actions of all compounds, growth hormone may lodge more than one of the isolated growth factors mentioned above.
Another investigator treated a woman with Sheehan's syndrome in a dilated cardiomyopathy. Treatment in this case resulted in suppression of the dilated cardiomyopathy when the human growth hormone was continuously administered.
In all of the above-described cases the use of the hormone or the isolated growth factors brought beneficial results.
The inventor's published experimental investigations in rats and pigs have shown the ability to reconstruct the ventricular wall and to recognize other mechanisms linked to this treatment of myocardial ischemialacute necrosis.
SUMMARY OF THE INVENTION
It is an aspect of the invention to provide a method of treatment for acute myocardial infarction using human growth hormone.
It is an aspect of the invention to provide a method of treatment for acute myocardial infarction that provides a reduction of extension and intensity of the running necrosis limiting itself to a piece-meal type one, with partial intracellular lesions.
It is another aspect of the invention to a method of treatment for acute myocardial infarction that provides an absence of slippage and septal/ventricular ruptures.
Another aspect of the invention is to provide a method of treatment for acute myocardial infarction that reduces the incidence of ventricular aneurysms.
It is still another aspect of the invention to a method of treatment for acute myocardial infarction that restores the contractility in the previously affected, achynetic area.
It is another aspect of the invention to a method of treatment for acute myocardial infarction that improves the ventricular function.
It is another aspect of the invention to a method of treatment for acute myocardial infarction that lessens the incidence of ventricular arrythmias.
Finally, it is another aspect of the invention to a method of treatment for acute myocardial infarction that provides a beneficial treatment of cardiac failure.
The invention is a method of treating a patient to reduce heart damage associated with an acute myocardial infarction. The treatment comprises several first steps. First, a patient is selected based on a plurality of predetermined criteria to establish that the method of treatment is indicated. Then, the method of treatment is begun at a time ranging from immediately post onset to not more than ten hours post onset of the acute myocardial. Next, the patient is injected with an efficacious dose of human growth hormone for a predetermined period of time. Finally, the patient is tested on predetermined schedule to measure the effectiveness of the treatment. The damage to the patient's heart due to the acute myocardial infarction is substantially reduced than would be found if the patient had been untreated.
REFERENCES:
patent: 5140008 (1992-08-01), Jorgensen
patent: 5849704 (1998-12-01), Sorensen
Castagnino et al. “Preservation of the Myocardial Collagen Framework by Human Growth-Hormone in Experimental Infarctions and reduction in the Incidence of Ventricular Aneurysms”, 1992 (Abstract Only) Intnl J Card, 35(1): pp. 101-114.*
Novo Nordisk fact sheet for human growth hormone: 8/2000 HTTP://health.novo.dk/health/hgh/facts.asp.
Isabella David J.
O'Hara Kelly
Ritchie William B.
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