2-Decarboxy-2-hydroxymethyl-13,14-didehydro-17-phenyl-PGA, PGD a

Details 2-Decarboxy-2-hydroxymethyl-13,14-didehydro-17-phenyl-PGA, PGD a 2-Decarboxy-2-hydroxymethyl-13,14-didehydro-17-phenyl-PGA, PGD a

1978-02-24

1979-02-20

Thomas, Jr., Jaems O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C 4978

Patent

active

041407210

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol and the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostanglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3935254 (1976-01-01), Gandolfe et al.
patent: 3984400 (1976-10-01), Eggler et al.

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