Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-11-21
1988-07-26
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 77, A61K 3158, C07J 7300
Patent
active
047600713
ABSTRACT:
This invention is for the compound 17.beta.-(N-t-butylcarbamoyl)-4-aza-5.alpha.-androst-1-en-3-one, pharmaceutical compositions containing the compound, methods of inhibiting testosterone 5.alpha.-reductase with the compound and methods of treating hyperandrogenic conditions with the compound, particularly benign prostatic hypertrophy.
REFERENCES:
patent: 2227876 (1941-01-01), Bolt
patent: 3239417 (1966-03-01), Di Tullio et al.
patent: 3264301 (1966-08-01), Doorenbos et al.
patent: 3285918 (1966-11-01), Doorenbos et al.
patent: 4220775 (1980-09-01), Rasmusson et al.
patent: 4377584 (1983-03-01), Rasmusson et al.
Brooks, et al., The Prostate, vol. 9, pp. 65-75, (1986).
Neri et al., A Biological Profile of a Nonsteroidal Antiandrogen, Endo, 1972, vol. 91, No. 2, pp. 427-437.
Nayfe et al., Metabolism of Progesterone by Rat Testicular Homogenates, 9/69, Steroids, pp. 269-283.
Doorenbos & Solomons; Synthesis & Antimicrobial Properties of 17.beta.-Isopentyloxy-4-aza-5.alpha.-androstane & 4-Methyl Derivative; J. Pharm. Sci. 62, 4, pp. 638-640, (1973).
Doorenbos & Brown; 4,17.alpha.-Dimethyl-4-aza-5.alpha.-androstan-17.beta.-ol Acetate & Related Azasteroids; J. Pharm. Sci. 60,4, pp. 1234-1235, (1971).
Doorenbos & Kim., Synthesis & Evaluation of Antimicrobial Propertes of Amidinoazaandrostane & Quanidinoazaandrostanes; J. Pharm. Sci., 63,4, pp. 620-622, (1974).
Kedderis, G. L. et al., "Studies with Nitrogen-Containing Steroids and Freshly Isolated Rat Hepatocytes: Role of Cytochrome P-450 in Detoxication," J. Tox. Appl. Pharm., (in press).
Rasmusson Gary H.
Reynolds Glenn F.
Caruso Charles M.
Daus Donald G.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Rivers Diana G.
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