Certain pyridyl alkenoic acid derivatives which inhibit the acti

Details Certain pyridyl alkenoic acid derivatives which inhibit the acti Certain pyridyl alkenoic acid derivatives which inhibit the acti

1986-06-06

1988-07-26

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514332, 514336, 514337, 514338, 546266, 546267, 546270, 546274, 546283, 546284, 546342, C07D21355, C07D40106, C07D40906, A61K 3144

Patent

active

047600683

ABSTRACT:
Novel compound of the formula: ##STR1## wherein R.sup.1 is pyridyl group, R.sup.2 is a phenyl group, a thienyl group, a furyl group, a naphthyl group, a benzothienyl group or pyridyl group, which may optionally have a lower alkoxy group, a lower alkyl group, a halogen atom, trifluoromethyl group, a lower alkenyl group or methylenedioxy group, R.sup.3 is hydrogen atom or a lower alkyl group, and n is an integer of 0 to 6, Y is sulphur atom, methylene group or a group of the formula: ##STR2## wherein R.sup.4 is hydrogen atom or acetyl group, and m is 0 or 1, and their pharmaceutically acceptable salts having an inhibitory action on bio-synthesis of thromboxane A.sub.2 (TXA.sub.2) and an effect of accelerating the productivility of prostaglandin I.sub.2 (PGI.sub.2), and can be used for mammals to the prophylaxis or therapy of thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardiac infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

REFERENCES:
patent: 4518602 (1985-05-01), Terao et al.
patent: 4563446 (1986-01-01), Terao et al.

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