Antisense inhibition of G-alpha-i3 expression

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology

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435 6, 435 911, 435325, 435366, 536 231, 536 2433, 536 245, C12Q 168, C12N 1500, C07H 2104

Type

Patent

Status

active

Patent number

060636262

Description

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of G-alpha-i3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G-alpha-i3. Methods of using these compounds for modulation of G-alpha-i3 expression and for treatment of diseases associated with expression of G-alpha-i3 are provided.

REFERENCES:
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Redmond et al., Flow-mediated regulation of G-protein expression in cocultured vascular smooth muscle and endothelial cells, Arterioscler. Thromb. Vasc. Biol., 1998, 18:75-83.
Schmidt et al., Alterations in guanine nucleotide regulatory protein expression and activity in human hepatocellular carcinoma, Hepatology, 1997, 26:1189-1194.
Wise et al., Interactions of the alpha2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants, Biochem. J., 1997, 321:721-728.
Wu et al., Inhibition of phospholipase C blocks opioid receptor-mediated activation of Gi proteins, Neuroreport., 1998, 9:99-103.
Voisin et al. J. Biol. Chem. 271:547-580, 1996.
Takano et al. J. Physiol. 502(3):559-567, 1997.

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