Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Blood
Reexamination Certificate
1993-03-15
2001-10-16
Witz, Jean C. (Department: 1651)
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Blood
C424S530000, C424S531000, C424S532000, C424S533000, C424S534000, C424S545000
Reexamination Certificate
active
06303152
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to a process for the production of germicidally treated and/or immune-modulatory active substances and to the use of the substance produced by this process, referred to for brevity as a “suspension”, in particular to influence the immune system in the human and animal organism.
2. Brief Description of the Background of the Invention Including Prior Art
In the present state of medical science and technology, there are various ways of influencing the immune system of the body.
An example is by passive or active vaccination, i.e. by the stimulation of antibodies or by the direct application of antibodies, whereby either suppressive or stimulatory processes can be produced (definitions of medical terms in particular according to “Pschyrembel” clinical dictionary, Walter de Gruyter, Berlin-New York, 1977).
Desensitization has achieved particular importance in which the triggering antigen is first introduced to the organism at a very high dilution and then in increasing doses, so as to neutralize the excessive antibody reactions. Disadvantages of this process are the low success rate, the very prolonged treatment time, and the relatively limited spectrum of indication of allergic illnesses.
A simple yet successful process is the injection of autologous blood. One such process is known in which dilutions of autologous blood are treated with suspensions of aluminum hydroxide, analogous to the binding of vaccines on aluminum hydroxide in processes known to date, whereby the binding of the protein on the oxide certainly produces not only a certain depot effect for the erythrocyte material and the plasma proteins, but also a partial isolation of immune-relevant proteins.
This process has not achieved any great acceptance since it does not work reliably in the broad spectrum of indications.
Another method that should also be mentioned is an alternative method in which the patient's blood is very strongly oxidized by an ozone-oxygen mixture and then returned to the organism. Individual observations indicate that here immune-modulatory processes are triggered, too.
The use of suspensions for oxidation therapy is also described in particular in German Patent Specification 31 09 691, which refers to the autohemotherapy of Wolff, and more particularly, to the hyperbaric ozone therapy using venous blood of Kief, for which a device for extracorporeal bacteriocidal treatment is elaborated upon. The oxidation process of Wehrlie is also described.
In the proposals of Wolff and Kief, blood from the patient's body, and this alone, is used as the initial substance and subjected to an oxidation treatment and then reinfused as such. This is thus done in an exclusive manner, and there is only one oxidation step.
SUMMARY OF THE INVENTION
1. Purposes of the Invention
It is an object of the invention to provide a process for influencing the immune system of mammals.
It is another object of the invention to provide a method for creating suppressive and stimulative effects in a mammal.
It is a further object of the invention to provide a method of producing an oxidized blood.
These and other objects and advantages of the present invention will become evident from the description which follows.
2. Brief Description of the Invention
The invention is based on the observation that oxidized autologous blood can, in some cases, exhibit suppressive effects while in other similar cases it can show a stimulatory effect. Elucidation of this contradictory observation led to the discovery that oxidized or ozonized plasma often has an immune-suppressive effect, while a similarly treated erythrocyte concentrate just as often has an immune-stimulatory effect. Further clarification of exact occurrence led to the discovery that even deproteinized serum can still trigger immune-modulatory processes.
Urine which in this respect can be regarded in a somewhat simplified manner as an electrolyte solution that has been filtered from the blood through the kidneys and selectively concentrated can, when administered by injection, also trigger immune processes.
While the use of urine as a “desensitizing agent” was formerly often practiced in naturopathic medicine, it has since been forgotten due to the fact that the disinfecting additives usually employed in the past, namely thymol and phenol, are themselves somewhat toxic and are unsuitable for use as additives. However, urine cannot be used unfiltered and unsterilized because of the risk of injection abscesses.
Based on these discoveries it is disclosed, according to the invention, to fractionate the initial substance which, besides human or animal blood, can also be a tissue or an initial substance multiplied by culturing, or even urine.
The novel features which are considered as characteristic for the invention are set forth in the appended claims.
The invention itself, however, both as to its construction and its method of operation, together with additional objects and advantages thereof, will be best understood from the following description of specific embodiments when read in connection with the accompanying drawings.
REFERENCES:
patent: 4632980 (1986-12-01), Zee et al.
patent: 4684521 (1987-08-01), Edelson
patent: 4748120 (1988-05-01), Wiesehahn
patent: 3109691 (1982-09-01), None
Levy & Grandinetti
Witz Jean C.
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