Assay for D-1 antagonistic activity of neuroleptic drugs

Details Assay for D-1 antagonistic activity of neuroleptic drugs Assay for D-1 antagonistic activity of neuroleptic drugs

1984-11-19

1988-07-26

Marantz, Sidney

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

Utilizing isolate of tissue or organ as binding agent

436501, 436503, 436804, 436815, 540504, G01N 33566, G01N 33567

Patent

active

047600292

ABSTRACT:
A method, reagents, and kit for determining the levels of D-1 receptor antagonistic activity of neuroleptic drugs. The method correlates competition between analyte and tritiated R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol for binding to D-1 receptors in mammalian brain tissue.

REFERENCES:
Billard, W. et al., Life Sciences, 35:1885-1893, (1984).
Hyttel, J., (1983), Eur. Jour. Pharm., 91:153-154.
Billard, W., et al., (1984), Chem. Abstr., vol. 101: abstract No. 184777s.

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