Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Solid support and method of culturing cells on said solid...
Reexamination Certificate
1999-01-26
2001-11-20
Lankford, Jr., Leon B. (Department: 1651)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Solid support and method of culturing cells on said solid...
C435S401000, C435S402000, C623S011110
Reexamination Certificate
active
06319712
ABSTRACT:
BACKGROUND ART
The invention relates to a biohybrid joint or articular surface replacement.
For the treatment of damaged articular cartilages, e. g. caused by deformities, injuries or degenerative diseases, development work is concentrated on the production of replacement cartilages, which can be implanted in the patient.
Of late processes for producing implants from cell cultures have become known, such as are e. g. described in the Sittinger international patent application WO 94/20151. Cartilage cells are produced in vitro in cavities of a three-dimensional carrier structure.
The Vacanti WO 90/12603 discloses a system for the in vivo neomorphogenesis of cartilage cells from a cell culture.
The cartilage implants known from the prior art suffer from a number of disadvantages.
A reliable fixing in the subchondral bone is important for a completely satisfactory articular replacement surface replacement. For this purpose the implant must be held by complicated suture techniques or fastening clips.
An important problem in the therapy of pathological changes to articular surfaces is the penetration of synovial fluid, whose constituents, such as hyaluronic acid, impair regeneration and growing in. The synovial fluid, which flushes round the inserted implant, prevents an attachment of the cartilage structure to the defect boundaries and to the bone.
The hitherto known cartilage substitute materials for the treatment of articular defects are unable to fulfill the requisite criteria for a successful, durable healing, such as reliable and simple fastening to the bone, rapid growing in, physiological restoration of the articular structure and permanent functionality.
The problem therefore arises of providing an articular surface replacement, which is formed from cartilage cells in a three-dimensional structure, which is simple and reliable to produce under standard biomedical conditions and with existing equipment.
SUMMARY OF THE INVENTION
This problem is solved by a biohybrid articular surface replacement in the form of a three-dimensional, porous carrier, in which cartilage cells can be cultured in vitro and/or in vivo to a three-dimensional cell union and following cell growth, and optionally after the development of tissue, can be placed on the exposed bone in the vicinity of (that is in place of) a defective articular surface and which is characterized in that the carrier, on the side intended for application to the bone, has material for aiding osseous integration.
In the following said material for aiding osseous integration is called bone integration aid.
REFERENCES:
patent: 4365357 (1982-12-01), Draenert
patent: 4457028 (1984-07-01), Draenert
patent: 5041138 (1991-08-01), Vacanti
patent: 5674292 (1997-10-01), Tucker et al.
patent: 5700289 (1997-12-01), Breitbart et al.
patent: 5736372 (1998-04-01), Vacanti
patent: 5855608 (1999-01-01), Brekke et al.
patent: 5891455 (1999-04-01), Sittinger et al.
patent: 5981825 (1999-11-01), Brekke
patent: 6013856 (2000-01-01), Tucker et al.
patent: 6028242 (2000-02-01), Tucker et al.
patent: 0714666A1 (1995-11-01), None
patent: 90/12603 (1990-11-01), None
patent: 94/20151 (1994-09-01), None
patent: WO94/26211 (1994-11-01), None
patent: WO95/31157 (1995-11-01), None
patent: WO95/33502 (1995-12-01), None
patent: WO97/14783 (1997-04-01), None
Dauner Martin
Meenen Norbert M.
Planck Heinrich
Deutsche Institute fur Textil-und Faserforschung Stuttgart
Lankford , Jr. Leon B.
Pennie & Edmonds LLP
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