N-morpholino derivatives and their use as anti-hypertensive agen

Details N-morpholino derivatives and their use as anti-hypertensive agen N-morpholino derivatives and their use as anti-hypertensive agen

1989-12-14

1991-10-08

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142368, 5142338, 5142345, 5142372, 5142352, 514212, 5142278, 514252, 514253, 514255, 514318, 514321, 514322, 514326, 544133, 544135, 544137, 544139, 544131, 544140, 544143, 544 581, 544369, 544368, 544370, 544371, 544372, 544360, 540602, 540603, 546193, 546194, 546198, 546199, 546208, 546209, 546210, 546211, A61K 3138, A61K 31415, A61K 3144, A61K 31495, C07D41500, C07D41312, C07D41712, C07D21168

Patent

active

050554662

ABSTRACT:
Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.

REFERENCES:
patent: 4477441 (1984-10-01), Boger et al.
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patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4629724 (1986-12-01), Ryono et al.
Toda et al., "Human Renin Inhibiting Dipeptide", European Jour. of Pharmacology, 129, 1986, 393-396.
Miyazaki et al., "Orally Active Renin Inhibiting Dipeptide", (Abstract of talk at American Society of Hypertension Conf. in New York, 1987).
Rasetti et al., "European Federation for Medicinal Chemistry's 9th Symposium on Medicinal Chemistry", West Berlin, Sep. 9-18, 1988.
S. H. Rosenberg et al., "Novel Renin Inhibitors Containing Analogues of Statine Retro-Inverted at the C-Termini: Specificity at the P.sub.2 Histidine Site", J. Med. Chem., 1987, vol. 30, No. 7, pp. 1224-1228.
H. L. Sham et al., "Novel Non-Basic Bioisostere of Histidine Synthesized from L-Aspartic Acid", J. Chem. Soc., Chem. Commun., pp. 1792-1793 (1987).

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