13-epi-avermectin derivatives useful as antiparasitic agents

Details 13-epi-avermectin derivatives useful as antiparasitic agents 13-epi-avermectin derivatives useful as antiparasitic agents

1989-10-30

1991-10-08

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514450, 514336, 549264, 536 71, 546268, A61K 3170, C07D31500

Patent

active

050554549

ABSTRACT:
There are disclosed avermectin derivatives in which position 13 of the avermectins has been inverted from the normal (alpha) stereoschemistry to the epimeric 13-beta stereochemistry. The synthetic 13-epi analogs are derived from the corresponding aglycones which in turn are prepared by chemical modification of naturally occurring avermectins. The compounds are active antiparasitic agents and compositions for that use are disclosed.

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Carter et al., J. Antibiotics, 41, pp. 519-529 (1988).
Blizzard et al., J. Org. Chem., 54, p. 1756 (1989).

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