Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1998-08-20
2000-05-16
Lankford, Jr., Leon B.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424 941, 424 946, 424 9462, 435200, 435201, 435232, A61K 3847, A61K 3846
Patent
active
060633786
ABSTRACT:
A pharmaceutical composition and an agent that can be used for treatment of epidurally migrating herniated intervertebral disc are provided. The composition comprises a glycosaminoglycan degrading enzyme, preferably chondroitinase, more preferably chondroitinase ABC, in an amount effective to dissolve nucleus pulposus epidurally existing.
REFERENCES:
patent: 4696816 (1987-09-01), Brown
patent: 5496718 (1996-03-01), Hasimoto et al.
Tsuneto Sugimura, et al., Experimental Chemonucleolysis With Chondroitinase ABC in Monkeys, Spine vol. 21, No. 2 p. 1610165, 1996.
Toyomi Takahashi, et al., Treatment of Canine Intervertebral Disc Displacement With Chondroitinase ABC., Spine vol. 22, No. 13, pp. 1435-1439, 1997.
Comparison of Tissue Reaction with Chondroitinase ABC and Chymopapain in Rabbits as the Basis of Clinical Application in Chemonucleolysis, Fumihiko Kato M.D., et al., Clinical Orthopaedics and Related Research No. 288 Mar. 1993, pp. 294-302.
Chondroitinase ABC (Pharmaceutical Grade) for Chemonucleolysis, Kjell Olmarker, MD. PhD. et al., Spine, vol. 21, No. 17, 1996, pp. 1952-1956.
Ishikawa Hiroki
Nohara Yutaka
Lankford , Jr. Leon B.
Seikagaku Corporation
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