Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Bone
Reexamination Certificate
1999-02-19
2001-10-30
Prebilic, Paul B. (Department: 3738)
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
Bone
C623S023610, C523S116000, C433S228100
Reexamination Certificate
active
06309422
ABSTRACT:
BACKGROUND OF THE INVENTION
Field of the Invention
The present invention relates to a challenging aspect of synthetic bone grafting in medicine by developing a material that mimics real bone. Ultimately, the implanted material will either be replaced or incorporated by new, natural bone. Hydroxyapatite, a form of calcium phosphate, can be used as a bone graft, but implantation of this material results in no resorption, a requirement for the incorporation of new, natural bone. Small crystals of calcium phosphate compounds have also been used for this purpose, but the material does not have the structural strength to remain within the site of implantation. It is resorbed too quickly to allow for the incorporation of new bone. Another problem concerning the use of calcium phosphate involves the handling of this material. The handling and shaping of hydroxyapatite and small crystals of calcium phosphate compounds are extremely difficult, because these materials lack malleability, cohesiveness and the ability to adhere to bone surfaces.
Our material can replace hydroxyapatite and small crystals of calcium phosphate as bone grating material. It has cohesiveness, malleability, and structural strength, which are qualities that can improve the task of bone grafting. The malleability allows for medical professionals to handle and shape the material with ease, facilitating bone grafting procedures. The cohesiveness and structural strength of the material increase its chance for success in adhering to the bone defect site, resulting in a higher possibility for new bone to replace or incorporate the bone grating material within the defect site.
SUMMARY OF THE INVENTION
A challenging aspect of synthetic bone grafting in medicine is developing a material that can mimic the normal characteristics of healthy bone. Hydroxyapatite, a form of calcium phosphate, can be used as a bone graft, but implantation of this material results in no resorption, a requirement for the incorporation of new, natural bone. Small crystals of calcium phosphate compounds have also been used for this purpose, but the material does not have the structural strength to remain within the site of implantation. It is resorbed too quickly to allow for incorporation of new bone. Another problem concerning the use of pure calcium phosphate involves the handling of this material. The handling and shaping of hydroxyapatite and small crystals of calcium phosphate compounds is extremely difficult, because these materials lack cohesiveness and the ability to adhere to bone surfaces.
Implantation of calcium phosphate that contains protein could promote new bone growth by allowing the body to digest the protein away and build a cavernous system within the material. In addition, calcium phosphate that contains protein has greater structural strength than any calcium phosphate compound without protein, allowing the material to stay within the defect long enough for the body to proceed with natural bone replacement.
This document describes a material that incorporates any calcium containing compound and a protein. The protein provides the strength, elasticity, and malleability of the material. It also allows for the body to resorb and replace the protein with its own pre-bone materials and use the calcium compound within the bone grafting material to deposit natural bone. Any protein can be used, although vegetable protein is preferred, such as gluten, glutenin or gliadin. Combinations of different proteins can also be used.
BRIEF DESCRIPTION
The material of the synthetic bone graft is a mixture that contains specific amounts of any form of any calcium containing compound and protein. Vegetable protein is preferred, such as gluten, glutenin and gliadin, or a combination thereof. Adding water to the mixture results in the formation of a protein matrix which incorporates the calcium containing compound. This material could be used as a bone graft for periodontal, jaw, and other bone defects.
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patent: 4869906 (1989-09-01), Dingeldein et al.
patent: 4904585 (1990-02-01), Shimada et al.
patent: 5455231 (1995-10-01), Constantz et al.
patent: 5580623 (1996-12-01), Fulmer et al.
patent: 98/58602 (1998-12-01), None
Farrington Alfred
Huang Frank K.
Farrington Alfred
Mitchell Silberberg & Knupp LLP
Prebilic Paul B.
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