Aminopropanol derivatives of 6-hydroxy-2,3,4,5-tetrahydro-1H-1-b

Details Aminopropanol derivatives of 6-hydroxy-2,3,4,5-tetrahydro-1H-1-b Aminopropanol derivatives of 6-hydroxy-2,3,4,5-tetrahydro-1H-1-b

1981-01-19

1982-07-20

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602393B, A61K 3155, C07D22316

Patent

active

043405959

ABSTRACT:
Aminopropanol derivatives of 6-hydroxy-2,3,4,5-tetrahydro-1-H-1-benzazepin-2-one of the formula ##STR1## where R is alkyl of 1 to 6 carbon atoms, which is unsubstituted or substituted by hydroxyl or by alkoxy of 1 to 3 carbon atoms, or is alkenyl or alkynyl of 3 to 6 carbon atoms or is cycloalkyl of 3 to 7 carbon atoms in the ring, and their physiologically acceptable addition salts with acids, their preparation and pharmaceutical formulations, containing the said compounds, which because of their .beta.-sympatholytic action can be used as cardiac and circulatory drugs.

REFERENCES:
Shtacher et al., "J. Med. Chem.", vol. 16, No. 5, pp. 516-519 (1973).
Nakagawa et al., "J. Med. Chem.", vol. 17, No. 5, pp. 529-532 (1974).
Erez et al., "J. Med. Chem.", vol. 21, No. 9, pp. 982-984 (1978).
Handbook of Experimental Pharmacology (Springer-Verlag) (1977), Oates et al., pp. 598-599.
Japan J. Pharmacol., vol. 24, pp. 853-861, (1974) Yabuuchi et al.
Japan J. Pharmacol., vol. 24, pp. 863-868, (1974) Sasa et al.

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