Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-12-11
1998-10-20
Loring, Susan A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 221, 4352523, C07H 2104, C07H 1900, C12N 120
Patent
active
058247912
ABSTRACT:
DNA fragments from Porphyromonas gingivalis which express proteins that elicit anti-P. gingivalis immunologic responses are described. Microorganisms, genetically modified to express P. gingivalis antigens, are provided. Also disclosed are probes, vaccines, and monoclonal antibodies for the detection and prevention of periodontal disease.
REFERENCES:
patent: 4358535 (1982-11-01), Falkow et al.
patent: 4661350 (1987-04-01), Tsurumizu et al.
patent: 4866167 (1989-09-01), Chen et al.
patent: 5475097 (1995-12-01), Travis et al.
patent: 5523390 (1996-06-01), Travis et al.
Houghten et al. Vaccine 86, Cold Spring Harbor Laboratory, pp. 21-25, 1986.
Data base Search for Kirszhoun et al.
Progulske-Fox et al J. Periodontal Res 28:473-4, 1993.
Progulske-Fox Oral Microbiol Immunol 10:311-318, 1995.
Benas et al. Nucleic Acids Research 19:4189-4192, 1991.
Data base search for Banas.
Lepine Dissertation, pp. 73-80, 118-148, 170, 204-213 Apr., 1994.
White, D., D. Mayrand (1981) "Association of oral Bacteriodes with gingivitis and adult periodontitis" Journal of Periodontal Research 16:259-265.
Takazoe, I. et al. (1984) "Colonization of the Subgingival Area by Bacteriodes gingivalis" J. Dent. Res. 63(3):422-426.
Slots, J., E. Hausmann (1979) "Longitudinal Study of Experimentally Induced Periodontal Disease in Macaca arctoides: Relationship Between Microflora and Alveolar Bone Loss" Infection and Immunity 23(2):260-269.
Boyd, J., B. C. McBride (1984) "Fractionation of Hemagglutinating and Bacterial Binding Adhesins of Bacteriodes gingivalis" Infection and Immunity 45(2):403-409.
Inoshita, E. et al. (1986) "Isolation and Some Properties of Exohemagglutinin from the Cuture Medium of Bacteriodes gingivalis381" Infection and Immunity 52(2):421-427.
Okuda, K. et al. (1986) "Purification and Properties of Hemaggluitnin from Culture Supernatant of Bacteriodes gingivalis" Infection and Immunity 54(3):659-665.
Naito, Y. et al. (1987) "Detection of Specific Antibody in Adult Human Periodontis Sera to Surface Antigens of Bacteriodes gingivalis" Infection and Immunity 55(3):832-834.
Naito, Y. et al. (1985) "Monoclonal Antibodies against Surface Antigens of Bacteriodes gingivalis" Infection and Immunity 50(1);231-235.
Okuda, K. et al. (1986) "Antigenic Characteristics and Serological Identification of 10 Black-Pigmented Bacteroides Species" Journal of Clinical Microbiology 24(1):89-95.
Abiko, Y. et al. (1988) "Gene Cloning and Expression of a Bacteroides gingivalis-Specific Protein Antigen in Escherichia coli" Adv. Dent. Res. 2(2):310-314.
Dickinson, D.P. et al. (1988) "Molecular Cloning and Sequencing of the Gene Encoding the Fimbrial Subunit Protein of Bacteroides gingivalis" Journal of Bacteriology 170(4):1658-1665.
Okuda, K. et al. (1988) "Protective Efficiacy of Active and Passive Immunizations against Experimental Infection with Bacteroides gingivalis in Ligated Hamsters" J. Dent. Res. 67(5):807-811.
Mouton, C. et al. (1989) "Immunochemical Identification and Preliminary Characterization of a Nonfimbrial Hemagglutinating Adhesion of Bacteroides gingivalis" Infection and Immunity 57(2):566-573.
Progulske-Fox, A. et al. (1989) "The expression and function of a Bacteroides gingivalis hemagglutinin gene in Escherichia coli" Oral Microbial. Immunol. 4:121-131.
Roberts, M.C. et al. (1987) "Chromosomal DNA Probes for the Identification of Bacteroides Species" Journal of General Microbiology 133:1423-1430.
Dickinson, D.P. et al. (1986) "Molecular Cloning of B. gingivalis Fimbrial Protein Subunit Gene" J. Dental. Res. 65:737, abstract No. 105.
Abiko, Y. (1986) "Cloning and Expression of Bacteroides gingivalis Antigen Gene into Escherichia coli" J. Dental Res. 65:737, abstract No. 106.
Kawamoti, Y. et al. (1991) "Purification and Immunochemical Characterization of a Recombinant Outer Membrane Protein from Bacteroides gingivalis" Int. J. Biochem. 23(10):1053-1061.
Roberts, M.C. et al. (1987) "Chromosomal DNA Probes for the Identification of Bacteroides Species" Journal of General Microbiology 133:1423-1430.
Lerner, R.A. et al. (1983) "The Development of Synthetic Vaccines" in The Biology of Immunologic Disease, Chapter 31, pp. 331-338.
Helfman, D.M., S.H. Hughes (1987) "Use of Antibodies to Screen cDNA Expression Libraries Prepared in Plasmid Vectors" Methods in Enzymology 152:451-457.
Helfman, D.M. et al. (1983) "Identification of clones that encode chicken tropomnyosin by direct Immunological screening of a cDNA expression library" Proc. Natl. Acad. Sci. USA 80:31-35.
Young, R.A., R.W. Davis (1983) "Efficient isolation of genes by using antibody probes" Proc. Natl. Acad. Sci. USA 80:1194-1198.
Hoiseth, S.K., B.A.D. Stocker (1981) "Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines" Nature 291:238-239.
Brown, A. et al. (1987) "An Attenuated aroA Salmonell typhimurium vaccine Elicits Humoral and Cellular Immunity to Cloned .beta.-Galactosidase in Mice" The Journal of Infectious Diseases 155(1):86-92.
Sadoff, J.C. et al. (1988) "Oral Salmonella typhimurium Vaccine Expressing Circumsporozoite Protein Protects Against Malaria" Science 24:336-338.
French, C.K. et al. (1987) "DNA Probe-Based Technology Compared to Standard Culture Methodology for the Detection of Periodontal Pathogens" 33(6):963.
Lepine, G. et al. (1994) "Cloning and Characterization of a Fourth Putative Hemagglutinin Gene from Porphyromonas gingivalis" 94th Meeting of the American Society for Microbiology, Las Vegas, NV, May 23-27, *abstract No. D-117.
Fletcher, H.M. et al. (1994) "Cloning and Characterization of a Protease Gene (prtH) from Porphyromonas ginivalis" Infection and Immunity 62(10):4279-4286.
Kirszbaum, L. et al. (1985) "Complete Nucleotide Sequence of a Gene prtR of Porphymonas gingivalis W50 Encoding a 132 kDa Protein that Contains an Arginine-Specific Thiol Endopeptidase Domain and a Haemagglutinin Domain" Biochemical and Biophysical Research Communications 207(1):424-431.
Pavloff, N. et al. (1995) "Moklecular Cloning and STructural Characterization of the ArgGingipain Proteinase of Porphyromonas gingivalis" The Journal of Biological Chemistry 270(3):1007-1010.
Hunt, J.M., D.H. Persing (1993) "acterial Detection" DNA Probes, pp. 525-564.
Dusek, D.M. et al. (1994) "Systemic and Mucsal Immune Responses in Mice Orally Immunzed with Avirulent Salmonella typhinurium Expressing a Cloned Porphyromonas gingivalis Hemagglutinin" Infectin and Immunity 62(5):1652-1657.
Han Naiming
Lantz Marilyn
Lepine Guylaine
Patti Joseph M.
Progulske-Fox Ann
Bencen, Esq. Gerard H.
Bencen, P.A. Gerard H.
Loring Susan A.
UAB Research Foundation
University of Florida
LandOfFree
Cloned porphyromonas gingivalis genes and probes for the detecti does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cloned porphyromonas gingivalis genes and probes for the detecti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cloned porphyromonas gingivalis genes and probes for the detecti will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-245461