Surgery – Diagnostic testing – Respiratory
Reexamination Certificate
1999-03-29
2001-07-17
Nasser, Robert L. (Department: 3736)
Surgery
Diagnostic testing
Respiratory
C600S538000, C600S586000
Reexamination Certificate
active
06261238
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a method, system and apparatus for the detection and analysis of body sounds in general and to a method, system and apparatus for the automatic detection and analysis of breath sounds in particular.
BACKGROUND OF THE INVENTION
The art of listening to body sounds, or auscultation, has been used by physicians for thousands of years, for diagnosing various diseases.
Auscultation was initially performed by placing the physician's ear directly on the skin of the patient. At the beginning of the 19th century, R. T. Laennec introduced a tool, the stethoscope, for transmitting of body sounds to the ear.
Currently used stethoscopes include a “chest piece” brought into contact with the patient's skin, and two flexible tubes, terminating in the physicians ears. Pulmonary sounds are typically classified into normal breath sounds and adventitious (abnormal) breath sounds. The type of adventitious breath sounds, their temporal location relative to the inspiration and expiration phases of the respiratory cycle and their rate of occurrence are used to diagnose the nature and severity of pulmonary diseases.
Adventitious breath sounds are usually divided into continuous and discontinuous sounds depending on their duration Continuous sounds are further subdivided into wheezes, which are higher pitched musical sounds indicating the presence of airway narrowing and rhonchi, which are low-pitched, grinding sounds. Discontinuous adventitious breath sounds are similarly divided into coarse crackles, which are short intermittent explosive sounds having a lower pitch, and fine crackles, which are less loud, shorter in duration, and higher in pitch. Crackles are usually indicative of obstructive airway diseases or restrictive lung diseases (depending on their timing in the respiratory cycle). In addition, cough and snores are respiration—related acoustic signals whose presence reflect on the status of well-being of the pulmonary system.
The use of various sensors which transform the acoustic signals of the body into electrical voltages is well known in the art Various types of transducers have been used in implementing body sound sensors, including both air coupled and contact microphones or accelerometers. An improved contact sensor for body sounds has been disclosed by the present inventor in U.S. patent application 08/654,643 filed on May 29, 1996 and entitled “A Contact Sensor for Body Sounds”. The disclosure of this application is incorporated herein by reference.
The introduction of computerized signal processing methods has facilitated quantitative and objective analysis of breath sounds. Methods have been developed which transform the acoustic signals to the frequency domain, characterize the signals' temporal and spectral patterns, and extract features that distinguish the various classes of normal and abnormal breath sounds, as described in the book,
Breath Sounds Methodology
by Noam Gavriely, CRC Press Inc, 1995. Pages 1-196, Chapters 1-13, which is incorporated herein by reference.
U.S. Pat. No. 5,213,108 to Bredesen and Schmerler discloses a visual display stethoscope which enables the visual display of acoustic data including breath sounds and manual measurement of certain parameters of the acoustic waveform. Methods involving the manual analysis of visually displayed digitized waveforms are time consuming, require the analysis to be performed by an expert and lack objective and uniform criteria for quantitative identification of adventitious sounds.
Published PCT Application WO 91/03981 to Murphy discloses a system and method for automatically detecting and identifying certain adventitious sounds. The method of crackle identification is based on two primary parameters, the amplitude and duration of the crackle wave (half cycle), and on one secondary parameter, the slope of the crackle waves.
Crackle detection methods based on wave amplitude analysis as a primary detection criterion have an inherent disadvantage due to the fact that the amplitude of crackles is often similar to or even smaller than the amplitude of the underlying breath sounds. A simple threshold crossing criterion will miss the majority of crackles, thus rendering the rest of the analysis useless.
Nocturnal respiratory symptoms are common, yet difficult to assess. They include nighttime dyspnoea caused by cardiac, gastrointestinal and pulmonary disease processes. Paroxysmal nocturnal dyspnoea (PND) is a symptom of congestive heart failure (CHF) where water accumulates in the lung of the supine patient and interferes with alveolar gas exchange. This process leads to a sudden onset of breathlessness, usually during the third part of the night, which is relieved by shifting to an upright posture. Gastro-esophageal reflux of acidic content from the stomach in supine patients is often associated with aspiration of the acid into the airways that causes an acute onset of cough, wheezing and dyspnoea. A nighttime onset of asthma attacks is common in children. It is often suspected by the physician after hearing a description of the course of events by a parent, but an objective diagnosis is difficult. Especially since at least some of these children have normal physical examination and spirometry during the day. Another class of nocturnal breathing disorders is the obstructive sleep—apnea (OSA) syndrome and its related conditions hypopnea, snoring). In these conditions, the patient's upper airway collapses or becomes narrowed or flutter develops, leading to a complete or partial interruption of the flow. OSA causes interference with the normal pattern of sleep, multiple (some time as many as hundreds) arousals during the night and reduced oxygenation.
Each of these clinical conditions have distinct breath sound features. Progressive pulmonary water overload is initially associated with the generation of inspiratory crackles, with an increasing range of chest wall distribution, and eventually, the emerging of expiratory crackles and wheezes. In addition, there is a gradual increase in the respiratory rate (tachypnea). An acute onset of cough, wheezing and secretion sounds (rhonchi and expiratory crackles) is a marker of aspiration. Finally, a gradual onset of wheezing with or without coughing is associated with bronchial asthma.
A disadvantage of the prior art of manual auscultation is that it can not provide a reliable objective and continuous detection and documentation of the occurrence of nocturnal adventitious breath sounds with respect to time, and while the patient is sleeping. Thus, prior art auscultation methods do not provide a reliable objective method for accurately diagnosing and documenting respiratory symptoms.
SUMMARY OF THE PRESENT INVENTION
One aspect of the present invention involves the determination of the types of breath sounds, i.e., wheezes, crackles, snores produced by a patient based on their generation and transmission mechanisms.
This aspect of the invention is based on an understanding and analysis of the underlying physics, aerodynamics, acoustics and physiology of breath sounds. Since basic breath sounds are generated by acoustic emission from turbulent flow they generally have a broad band spectrum at the site of their generation These sounds often reverberate in the airways which results in broad resonant frequencies. Furthermore, sounds transmitted to the chest wall are attenuated by intervening tissue, air and bone which acts as a low pass acoustic filter. When the breath sounds are fitted to characteristic equations of breath sounds the change in attenuation properties (for example by the presence of pneumonia) are reflected in modification of coefficients of the equations.
In another aspect of the invention, breath sounds are detected and characterized using a two step process. Preferably these two steps include an initial screening based on the detection of one or more specific properties of the sought signals. This screening can be both positive (i.e., the presence of a sound pattern which is characteristic of the
Fenster & Company Patent Attorneys Ltd.
Karmel Medical Acoustic Technologies Ltd.
Nasser Robert L.
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