5-fluorouracil derivatives

Details 5-fluorouracil derivatives 5-fluorouracil derivatives

1986-09-03

1989-09-05

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1900

Patent

active

048640212

ABSTRACT:
An anticancer compound is disclosed which is represented by the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is a phenyl-lower alkyl optionally having a substituent, phenyl-lower alkenyl or naphthyl-lower alkyl, the other of R.sup.1 and R.sup.2 is hydrogen or acyl, and R.sup.3 is hydrogen, acyl or tetrahydrofuranyl, or represented by the formula ##STR2## wherein R.sup.x is an optionally substituted pyridyl, Y is arylene and .alpha. is a known 5-fluorouracil derivative residue which can be converted to 5-fluorouracil in vivo and which is linked to the carbonyl by an ester or amide linkage.

REFERENCES:
patent: 4124765 (1978-11-01), Kurono et al.
European Search Rpt. EP 85 11 3724 and attachment.
Chemical Abstracts, vol. 101, 1984, p. 657, Abstract 55487, dated 2/16/84.

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