Derivatives of 4'-demethyl-4-epipodophyllotoxin

Details Derivatives of 4'-demethyl-4-epipodophyllotoxin Derivatives of 4'-demethyl-4-epipodophyllotoxin

1984-07-18

1985-10-15

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 181, C07H 1524

Patent

active

045475679

ABSTRACT:
This invention relates to novel 4'-demethyl-4-epipodophyllotoxin derivatives represented by the general formula (I), and salts thereof: ##STR1## wherein R is a lower alkyl group, and X.sub.1 and X.sub.2 are independently a hydroxyl group or an amino group, the one being an amino group and the other being a hydroxyl group. These novel derivatives have a high carcinostatic activity and a relatively high water solubility and hence are expected to be useful as carcinostatics.

REFERENCES:
patent: 3060169 (1962-10-01), Stoll et al.
patent: 3408441 (1968-10-01), von Wartburg et al.
patent: 3524844 (1970-08-01), Keller-Juslem et al.

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