N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics a

Details N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics a N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics a

1984-02-24

1985-10-15

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 544295, 544357, 544359, 544360, 544391, 546276, A61K 31495, A61K 31505, C07D40300, C07D24102

Patent

active

045475059

ABSTRACT:
There are prepared new pharmacologically active compounds of the formula: ##STR1## In formula I R.sub.1 is a phenyl radical, pyridyl radical, a pyrimidyl group, or pyrazinyl radical, or a phenyl radical, pyridiyl radical, pyrimidyl radical, or pyrazinyl radical substituted by the radicals R.sub.3 and R.sub.4 which are the same or different and are hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, C.sub.1 -C.sub.6 -alkyl groups C.sub.1 -C.sub.6 -alkoxy groups, C.sub.3 -C.sub.6 -alkenyloxy groups, C.sub.3 -C.sub.6 -cycloalkyloxy groups, phenyl-C.sub.1 -C.sub.4 -alkoxy groups, C.sub.1 -C.sub.6 -alkylmercapto groups, the nitro group, the amino group, C.sub.1 -C.sub.6 -dialkylamino groups, C.sub.2 -C.sub.6 -alkanoyl groups, C.sub.2 -C.sub.6 -alkanoylamino groups, or C.sub.2 -C.sub.6 -alkanoyloxy groups and R.sub.2 is the adamantyl group, the 3,3-dimethyl-bicyclo[2.2.1]hept-2-yl radical, a saturated C.sub.3 -C.sub.16 -cycloalkenyl radical and alk is a straight or branched C.sub.1 -C.sub.6 alkyl chain.

REFERENCES:
Irikura, J. Med. Chem., vol. 11, 1968, pp. 801-804.
Petigara, J. Med. Chem., vol. 12, 1978, pp. 865-870.
Chem. Abst. vol. 89, 1978, item 109580c.
Irikura, Chem. Abst., 87:68418u.
Irikura, Chem. Abst., 87:68424t.
Irikura, Chem. Abst., 86:89893q.
Irikura, Chem. Abst. 87:135407e.

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