Process for producing optically active .gamma.-hydroxyketones

Details Process for producing optically active .gamma.-hydroxyketones Process for producing optically active .gamma.-hydroxyketones

1993-10-01

1994-09-20

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568315, 568316, 568396, 568392, 568394, C07C 4564

Patent

active

053491076

ABSTRACT:
Disclosed herein is a process for producing a .gamma.-hydroxyketone (2), which comprises asymmetrically hydrogenating a .gamma.-diketone (1) in the presence of a ruthenium-optically active phosphine complex as a catalyst ##STR1## wherein R.sup.1 and R.sup.2 mean individually an alkyl or phenyl group which may have a substituent group. According to the invention, optically active .gamma.-hydroxyketones useful in synthesizing optically active moiety in, biodegradable polymers, perfumes, intermediates for synthesizing medicines and the like can be efficiently prepared.

REFERENCES:
patent: 4916252 (1990-04-01), Sayo et al.
patent: 5066815 (1991-11-01), Sayo et al.
Bull. Soc. Chim. Belg., vol. 100, No. 8, 1991, H. Brunner, et al., "Asymmetrische Katalysen, 69 [1] Enantioselektive Hydrierung von Dicarbonylverbindungen Mit NaBr/L-(+)-Weinsaure Modifizierten Nickelkatalysatoren", pp. 585-595.

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