Process for preparing synthetic soil-extract materials and medic

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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4241951, A61K 3135, A01N 3578

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active

059454466

ABSTRACT:
Phenolic polymers are prepared by dissolving one or more organic phenols along with sodium periodate in aqueous base at pH 8-11, and allowing the mixtures to stand between 35 and 80.degree. C. for a period of 30 minutes to 100 hours. One or more inorganic compounds or salts is added and the solution is allowed to stand at room temperature between 2 and 48 hours. Salt molecules as well as starting compounds and other low molecular-weight materials below about 500 to about 10,000 daltons are removed from the product solutions. Purified phenolic polymers are prepared in concentrated aqueous solution or in dried powder form in a final step if necessary. The resultant phenolic polymers exhibit physicochemical properties strongly resembling those of typical commercially-available natural soil extracts. The materials are active anti-viral and anti-microbial agents, and are effective in anti-viral amounts in blood product compositions, in methods for reducing or eliminating virus in blood products and in anti-viral and anti-microbial compositions for treating or preventing human or animal viral or microbial diseases.

REFERENCES:
patent: 4999202 (1991-03-01), Cronje et al.
WO95/08335--PCT--Treatment of HIV Infection with Humic Acid--Mar. 30, 1995.
HealthGate Document--R. Ansorg et al.--Studies on the Antimicrobial Effect of Natural and Synthetic Humic Acids--Arzeimittelforschung 1978, 28(12), pp. 2195-2198.
HealthGate Document--K.D. Thiel et al.--Comparison of the in Vitro Activities of Ammonium Humate and of Enzymically Oxidized Chlorogenic anad Caffeic Acids Against Type 1 and Type 2 Human Herpes Virus--Pharmazie 1981, 36(1), pp. 50-53.
HealthGate Document--H. Schultz--Investigations on the Viricidal Effects of Humic Acids in Peat-Mull--Dtsch Tierarztl Wochenschr Jul. 1, 1965. 72(13), pp. 294-297.
HealthGate Document--R. Klocking et al.--Antiviral Properties of Humic Acids--Experientia May 15, 1972, 28(5), pp. 607-608.
HealthGate Document--G. Sydow et al.--The Effect of Phenolic Polymers on Retroviruses--Pharmazie Dec. 1986, 41(12), pp. 865-868.
R. Klocking and M. Sprossig--Experientia 1972 28(5)--pp. 607-608.
HealthGate Document--R. Klocking et al.--Antiviral Activity of Phenolic Polymers Against Type 1 Herpesvirus Hominis--Pharmazie Aug. 1978, 33(8), p. 539.
HealthGate Document--F. Schiller et al.--Results of an Oriented Clinical Trial of Ammonium Humate for the Local Treatment of Herpesvirus Hominus (HVH) Infections--Dermatol Monatsschr Jul. 1979, 165(7), pp. 505-509.
HealthGate Document--B. Helbig et al.--Therapeutic Effect of (E)-5-(2-Bromovinyl)2'-Deoxyuridine, Caffeic Acid Oxidation Product, and Trisodiumphosphonoformate on Cutaneous Herpes Simplex Virus Type 1 Infection in Guinea Pigs--J Med Virol Nov. 1987, 23(3), pp. 303-309.
R. Klocking--Interaction of Humic Acids and Humic-Acid-Like Polymers with Herpes Simplex Virus Type 1--Humanic Substances in the Aquatic and Terrestrial Environment, Berlin 1991, pp. 408-412.
HealthGate Document--In Vitro Studies of the Antiviral Activity of Enzymatically Oxidized O-Diphenolic Compounds Against Herpes Simplex Virus Type 1 and 2--Zentralbl Bakterios (Orig. A) Mar. 1979, 234(2), pp. 159-169.
HealthGate Document--K.D. Thiel et al.--In Vitro Studies of the Antiviral Activity of Ammonium Humate Against Herpes Simplex Virus Type 1 and Type 2--Zentralbl Bakteriol (Orig. A) Nov. 1977, 239(3), pp. 304-321.
HealthGate Document--K.D. Thiel et al.--Antiviral Activity of Enzymatically Oxidized Caffeic Acid Against Herpesvirus Hominis Type 1 and Type 2--Acta Virol May 1983, 27(3), pp. 200-208.
HealthGate Document--K.D. Theil et al.--Antiviral Effect of Enzymatically and Nonenzymatically Oxidized Caffeic and Hydrocaffeic Acids Against Herpesvirus Hominis Type 1 and Type 2 in Vitro--Pharmazie Nov. 1984, 39(11), pp. 781-782.
M. Cushman et al.--Preparation and Anti-HIV Activitites of Aurintricarboxylic Acid Fractions and Analogues: Direct Correlation of Antiviral Potency With Molecular Weight--Journal of Medicinal Chemistry 1991, 34(1), pp. 329-337.
M. Cushman et al.--Synthesis and Anti-HIV Activities of Low Molecular Weight Aurintricarboxylic Acid Fragments and Related Compounds--Journal of Medicinal Chemistry 1991, vol. 34, pp. 337-342.
HealthGate Document--D. Schols et al.--Selective Inhibitory Activity of Polyhydroxcarboxylates Derived From Phenolic Compounds Against Human Immunodeficiency Virus Replication--J Acquir Immune Defic Syndr 1991, 4(7), pp. 677-685.
S. Loya et al.--Hexaprenoid Hydroquinones, Novel Inhibitors of the Reverse Transcriptase of Human Immunodeficiency Virus Type 1--Journal of Natural Products Dec. 1993, 56(12), pp. 2120-2125.
J. Schneider et al.--Inhibition of HIV-1 in Cell Culture by Synthetic Humate Analogues Derived From Hydroquinone: Mechanism of Inhibition--Virology 1996, 218(2), pp. 389-395.
HealthGate Document--R. Mentel et al.--Effectiveness of Phenol Body Polymers Against Influenza Virus A/KRASNODAR/101/59/H2N2--Biomed Biochim Acta 1983, 42(10), pp. 1353-1356.
HealthGate Document--J. Hills et al.--Inhibition of Several Strains of Influenza Virus Type A and B by Phenolic Polymers--Biomed Biochim Acta 1986, 45(9), pp. 1173-1179.
A. Jankowski et al.--A Randomized, Double-Blind Study on the Efficacy of Tolpa Torf Preparation (TTP) in the Treatment of Recurrent Respiratory Tract Infections--Arch Immunol Ther Exp (Warsz) 1993, 41(1), pp. 95-97.
R. Klocking et al.--Title?--Pharmazie 1977, 32, p. 297.
HealthGate Document--R. Klocking et al.--Preparation, Characterization and Antiviral Activity of Phenolic Polyers. 2. Antiviral Activity of Phenolic Polymers (Proceedings)--Pharmazie May 1979, 34(5-6), pp. 293-294.
HealthGate Document--R. Mentel et al. --Effectiveness of Phenol Body Polymers Against Influenza Virus A/KRASNODAR/101/59/H2N2--Biomed Biochim Acta 1983, 42(10), pp. 1353-1356.
HealthGate Document--H.P. Klocking et al.--Effect of Phenol Ring Polymers on the Release of Plasminogen Activators--Farmakol Toksikol Jan.-Feb. 1984, 47(1), pp. 93-95.
HealthGate Document--K.D.Theil et al.--Antiviral Effect of Enzymatically and Nonenzymatically Oxidized Caffeic and Hydrocaffeic Acids Against Herpesvirus Hominis Type 1 and Type 2 in Vitro--Pharmazie. 39: 11, 1984 Nov., 781-782.
J. Hills--Hemmung Ausgewahlter Influenzavirusstamme Der Typen A and B Durch Phenolkorperpolymerisate--Biomed Biochim Acta 1986, 45(9), pp. 1173-1179.
HealthGate Document--B. Helbig et al.--Therapeutic Effect of (E)-5-(2-Bromovinyl)-2-Deoxyuridine, Caffeic Acid Oxidation Product, and Trisodiumphosphonoformate on Cutaneous Herpes Simplex Virus Type 1 Infection in Guinea Pigs--J Med Virol Nov. 1987, 23(3), pp. 303-309.
K.I. Hanninen et al.--Synthesis and Characterization of Humic Acid-Like Polymers--The Science of the Total Environment 1987, 62, pp. 201-210.
R. Klocking et al.--Interaction of Humic Acids and Humic-Acid-Like Polymers with Herpes Simplex Virus Type 1 Humic Substances in the Aquatic and Terrestrial Environment New York--Springer-Verlag 1989, pp. 407-412.
D. Schols et al.--Selective Inhibitory Activity of Polyhydroxycarboxylates Derived From Phenolic Compounds Against Human Immunodeficiency Virus Replication--Journal of Acquired Immune Deficiency Syndromes 1991, 4(7), pp. 677-685.
M. Cushman et al.--Preparation and Anti-HIV Activities of Aurintricarboxylic Acid Fractions and Analogues: Direct Correlation of Antiviral Potency with Molecualr Weight--Journal of Medicinal Chemistry 1991, 34(1), pp. 329-337.
M. Cushman et al.--Synthesis and Anti-Hiv Activities of Low Molecular Weight Aurintricarboxylic Acid Fragments and Related Compounds--Journal of Medicinal Chemistry 1991, 34(1), pp. 337-342.
HealthGate Document--M. Robert-Gero et al.--Biochemical Study of Humus Action of a Proteolytic Enzyme on Natural and Synthetic Humic Polymers and Those of Microbial Origin--Ann Inst Pasteur (Paris) Dec. 1967, 113(6), pp. 903-909.
HealthGate Document--M. Jakubiec et al.--Comparison of the Effect of Natural and Synthetic Humates and EDTA on the Growth of Escherichia coli--** Abstract not available.
HealthGate Document--R. Ansorg et al.--Studies on the Antimicrob

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